1. Gene
  2. WDTC1 - WD and tetratricopeptide repeats 1 Gene

WDTC1 - WD and tetratricopeptide repeats 1 Gene

中文名称:WD 和四肽重复 1

种属: Homo sapiens

同用名: ADP; DCAF9

基因 ID: 23038 | 基因类型: protein coding

关于 WDTC1

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:27,234,441-27,308,636 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 28.2), heart (RPKM 14.1) and 25 other tissues.

功能概要

预测启用酶抑制剂活性;组蛋白结合活性;和组蛋白脱乙酰酶结合活性。预计参与脂肪酸生物合成过程的负调控。预计在几个过程的上游或内部起作用,包括细胞对胰岛素刺激的反应;葡萄糖代谢过程; RNA 聚合酶 II 对转录的负调控。预测位于核内。预计是 Cul4-RING E3 泛素连接酶复合物的一部分。预计在细胞质中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of fatty acid biosynthetic process. Predicted to act upstream of or within several processes, including cellular response to Insulin stimulus; glucose metabolic process; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of Cul4-RING E3 ubiquitin Ligase complex. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

WDTC1 基因产物(3)

mRNA Protein Name
NM_001276252.2 NP_001263181.1 WD and tetratricopeptide repeats protein 1 isoform a
NM_001410767.1 NP_001397696.1 WD and tetratricopeptide repeats protein 1 isoform c
NM_015023.5 NP_055838.2 WD and tetratricopeptide repeats protein 1 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16964240 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WDTC1 蛋白结构

WD40

WD40: WD domain, G-beta repeat (41 - 75)

WD40

WD40: WD domain, G-beta repeat (81 - 120)

WD40

WD40: WD domain, G-beta repeat (126 - 163)

TPR_11

TPR_11: TPR repeat (366 - 430)

TPR_2

TPR_2: Tetratricopeptide repeat (434 - 457)

WD40

WD40: WD domain, G-beta repeat (531 - 566)

WD40

WD40: WD domain, G-beta repeat (572 - 608)

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  • 677 a.a.
蛋白主名 其他名称

WD and tetratricopeptide repeats protein 1

DDB1 and CUL4 associated factor 9

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus WDTC1 RGD RGD:1310362
Felis catus WDTC1 VGNC VGNC:67067
Mus musculus WDTC1 MGD MGI:2685541
Canis familiaris WDTC1 VGNC VGNC:48400
Macaca mulatta WDTC1 VGNC VGNC:79784
Bos taurus WDTC1 VGNC VGNC:107027