2. Gene
  3. ZSWIM8 - zinc finger SWIM-type containing 8 Gene

ZSWIM8 - zinc finger SWIM-type containing 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指 SWIM 型 8

种属: Homo sapiens

同用名: KIAA0913

基因 ID: 23053 | 基因类型: protein coding

关于 ZSWIM8

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,785,606-73,801,793 (from NCBI)

This gene has 23 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 21.6), spleen (RPKM 16.0) and 25 other tissues.

功能概要

启用泛素连接酶-底物适配器活动。参与 miRNA 分解代谢过程的正调控；蛋白酶体介导的泛素依赖性蛋白质分解代谢过程；和蛋白质泛素化。 Cul3-RING 泛素连接酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Part of Cul3-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZSWIM8 基因产物(4)

mRNA Protein Name
NM_001242487.2 NP_001229416.1 zinc finger SWIM domain-containing protein 8 isoform 2
NM_001242488.2 NP_001229417.1 zinc finger SWIM domain-containing protein 8 isoform 3
NM_001367799.1 NP_001354728.1 zinc finger SWIM domain-containing protein 8 isoform 4
NM_015037.4 NP_055852.2 zinc finger SWIM domain-containing protein 8 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: 通过直接分析推断
33184234 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of miRNA catabolic process IDA
IDA: 通过直接分析推断
33184234 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
33184234 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
33184234 GOA
involved in target-directed miRNA degradation IMP
IMP: 通过突变表型推断
33184237 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Cul3-RING ubiquitin ligase complex IDA
IDA: 通过直接分析推断
33184234 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

zinc finger SWIM domain-containing protein 8

关联疾病

疾病名称 别名
Acromelic Frontonasal Dysostosis

AFND

Acromelic Frontonasal Dysplasia

Frontonasal Dysplasia Acromelic

Toriello Syndrome

Dysostosis, Acromelic Frontonasal

Sweet Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16206 ZSWIM8 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ZSWIM8 VGNC VGNC:37388
Canis familiaris ZSWIM8 VGNC VGNC:48861
Felis catus ZSWIM8 VGNC VGNC:67387
Macaca mulatta ZSWIM8 VGNC VGNC:79396
Rattus norvegicus ZSWIM8 RGD RGD:1309414
Mus musculus ZSWIM8 MGD MGI:1919156
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