2. Gene
  3. Sesn2 - sestrin 2 Gene

Sesn2 - sestrin 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: HI95; Ses2; SEST2

基因 ID: 230784 | 基因类型: protein coding

关于 Sesn2

功能概要

Enables GDP-dissociation inhibitor activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including positive regulation of lipophagy; protein kinase B signaling; and regulation of cAMP-dependent protein kinase activity. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system and retina. Orthologous to human SESN2 (sestrin 2). [provided by Alliance of Genome Resources, Apr 2022]

Sesn2 基因产物(1)

mRNA Protein Name
NM_144907.1 NP_659156.1 sestrin-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP-dissociation inhibitor activity IDA
IDA: 通过直接分析推断
25259925 MGI
enables PH domain binding IPI
IPI: 通过物理相互作用推断
31915252 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18692468 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within D-glucose import IMP
IMP: 通过突变表型推断
22958918 MGI
involved in DNA damage response, signal transduction by p53 class mediator IMP
IMP: 通过突变表型推断
18692468 MGI
acts upstream of or within activation of protein kinase activity IDA
IDA: 通过直接分析推断
31915252 MGI
involved in cellular response to amino acid stimulus IMP
IMP: 通过突变表型推断
25259925 MGI
involved in cellular response to oxidative stress IMP
IMP: 通过突变表型推断
23274085 MGI
acts upstream of or within fatty acid beta-oxidation IGI
IGI: 通过遗传相互作用推断
22958918 MGI
acts upstream of or within glucose homeostasis IGI
IGI: 通过遗传相互作用推断
22958918 MGI
acts upstream of or within mitochondrial DNA metabolic process IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within mitochondrion organization IMP
IMP: 通过突变表型推断
22958918 MGI
involved in negative regulation of TORC1 signaling IMP
IMP: 通过突变表型推断
24947615 MGI
involved in negative regulation of cell growth IDA
IDA: 通过直接分析推断
20203043 MGI
involved in negative regulation of translation in response to endoplasmic reticulum stress IMP
IMP: 通过突变表型推断
24947615 MGI
acts upstream of or within positive regulation of lipophagy IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within regulation of cAMP-dependent protein kinase activity IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within response to glucose IGI
IGI: 通过遗传相互作用推断
22958918 MGI
acts upstream of or within response to glucose IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within response to insulin IGI
IGI: 通过遗传相互作用推断
22958918 MGI
acts upstream of or within response to insulin IMP
IMP: 通过突变表型推断
22958918 MGI
acts upstream of or within triglyceride homeostasis IMP
IMP: 通过突变表型推断
22958918 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of TORC2 complex IDA
IDA: 通过直接分析推断
25377878 MGI
part of nucleotide-activated protein kinase complex IDA
IDA: 通过直接分析推断
18692468 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sestrin-2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12735 SESN2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20488 Sesn2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26996 Sesn2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sesn2 NCBI NCBI:83667
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