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  3. Tardbp - TAR DNA binding protein Gene

Tardbp - TAR DNA binding protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Tdp43; TDP-43; 1190002A23Rik

基因 ID: 230908 | 基因类型: protein coding

关于 Tardbp

功能概要

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and pre-mRNA intronic binding activity. Involved in positive regulation of protein import into nucleus; regulation of circadian rhythm; and regulation of protein stability. Acts upstream of or within RNA splicing. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and heart. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; amyotrophic lateral sclerosis type 10; and frontotemporal dementia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Orthologous to human TARDBP (TAR DNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Tardbp 基因产物(6)

mRNA Protein Name
NM_001003898.3 NP_001003898.1 TAR DNA-binding protein 43 isoform 5
NM_001003899.2 NP_001003899.1 TAR DNA-binding protein 43 isoform 3
NM_001008545.2 NP_001008545.1 TAR DNA-binding protein 43 isoform 2
NM_001008546.2 NP_001008546.1 TAR DNA-binding protein 43 isoform 4
NM_001305425.1 NP_001292354.1 TAR DNA-binding protein 43 isoform 6
NM_145556.4 NP_663531.1 TAR DNA-binding protein 43 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
27378374 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18836447 MGI
enables pre-mRNA intronic binding IDA
IDA: 通过直接分析推断
27378374 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
22570411 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within RNA splicing IMP
IMP: 通过突变表型推断
27378374 MGI
acts upstream of or within gene expression IMP
IMP: 通过突变表型推断
27378374 MGI
involved in positive regulation of protein import into nucleus IDA
IDA: 通过直接分析推断
28585542 MGI
involved in regulation of circadian rhythm IMP
IMP: 通过突变表型推断
27123980 MGI
involved in regulation of protein stability IMP
IMP: 通过突变表型推断
27123980 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
28585542 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

TAR DNA-binding protein 43

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS23806 Tardbp Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS14208 TARDBP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17352 Tardbp Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tardbp NCBI NCBI:23435
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