2. Gene
  3. ADGRL2 - adhesion G protein-coupled receptor L2 Gene

ADGRL2 - adhesion G protein-coupled receptor L2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 L2

种属: Homo sapiens

同用名: CL2; LEC1; CIRL2; LPHH1; LPHN2

基因 ID: 23266 | 基因类型: protein coding

关于 ADGRL2

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:81,306,132-81,993,932 (from NCBI)

This gene has 42 transcripts (splice variants), 199 orthologues and 42 paralogues. Ubiquitous expression in thyroid (RPKM 16.1), lung (RPKM 14.8) and 23 other tissues.

功能概要

该基因编码 G 蛋白偶联受体的 latrophilin 亚家族成员。编码的蛋白质参与胞吐作用的调节。前蛋白被认为在富含半胱氨酸的 G 蛋白偶联受体蛋白水解位点内被进一步切割成两条非共价结合在细胞膜上的链。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ADGRL2 基因产物(21)

mRNA Protein Name
NM_001297704.3 NP_001284633.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001297705.3 NP_001284634.1 adhesion G protein-coupled receptor L2 isoform 2 precursor
NM_001297706.3 NP_001284635.1 adhesion G protein-coupled receptor L2 isoform 3 precursor
NM_001330645.3 NP_001317574.1 adhesion G protein-coupled receptor L2 isoform 4 precursor
NM_001350698.2 NP_001337627.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001350699.2 NP_001337628.1 adhesion G protein-coupled receptor L2 isoform 6 precursor
NM_001366002.2 NP_001352931.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001366003.2 NP_001352932.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001366004.2 NP_001352933.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001366005.2 NP_001352934.1 adhesion G protein-coupled receptor L2 isoform 7 precursor
NM_001366006.2 NP_001352935.1 adhesion G protein-coupled receptor L2 isoform 7 precursor
NM_001366007.2 NP_001352936.1 adhesion G protein-coupled receptor L2 isoform 8 precursor
NM_001366008.2 NP_001352937.1 adhesion G protein-coupled receptor L2 isoform 9 precursor
NM_001366009.2 NP_001352938.1 adhesion G protein-coupled receptor L2 isoform 10 precursor
NM_001393349.1 NP_001380278.1 adhesion G protein-coupled receptor L2 isoform 5 precursor
NM_001393350.1 NP_001380279.1 adhesion G protein-coupled receptor L2 isoform 4 precursor
NM_001393351.1 NP_001380280.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001393352.1 NP_001380281.1 adhesion G protein-coupled receptor L2 isoform 1 precursor
NM_001393353.1 NP_001380282.1 adhesion G protein-coupled receptor L2 isoform 11 precursor
NM_001393354.1 NP_001380283.1 adhesion G protein-coupled receptor L2 isoform 6 precursor
NM_012302.5 NP_036434.1 adhesion G protein-coupled receptor L2 isoform 1 precursor

ADGRL2 蛋白结构

Gal_Lectin

Gal_Lectin: Galactose binding lectin domain (49 - 129)

OLF

OLF: Olfactomedin-like domain (140 - 393)

HRM

HRM: Hormone receptor domain (467 - 523)

(531 - 761)

GPS

GPS: GPCR proteolysis site, GPS, motif (785 - 831)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (846 - 1095)

Latrophilin

Latrophilin: Latrophilin Cytoplasmic C-terminal region (1115 - 1474)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1474 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor L2

calcium-independent alpha-latrotoxin receptor 2

关联疾病

疾病名称 别名
Eosinophilic Meningitis

Eosinophilic Meningoencephalitis Due To Angiostrongylus Cantonensis
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00362 ADGRL2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ADGRL2 VGNC VGNC:69632
Canis familiaris ADGRL2 VGNC VGNC:37651
Rattus norvegicus ADGRL2 RGD RGD:620835
Felis catus ADGRL2 VGNC VGNC:59639
Mus musculus ADGRL2 MGD MGI:2139714
Bos taurus ADGRL2 VGNC VGNC:53846
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