2. Gene
  3. ADGRL3 - adhesion G protein-coupled receptor L3 Gene

ADGRL3 - adhesion G protein-coupled receptor L3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：粘附 G 蛋白偶联受体 L3

种属: Homo sapiens

同用名: CL3; LEC3; CIRL3; LPHN3

基因 ID: 23284 | 基因类型: protein coding

关于 ADGRL3

Cytogenetic location: 4q13.1 Genomic coordinates (GRCh38): 4:61,200,326-62,078,335 (from NCBI)

This gene has 19 transcripts (splice variants), 211 orthologues and 42 paralogues. Biased expression in brain (RPKM 7.2), adrenal (RPKM 1.9) and 13 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 (GPCR) 的 latrophilin 亚家族成员。 Latrophilins 可能在细胞粘附和信号转导中发挥作用。在非人类物种的实验中，富含半胱氨酸的 GPS (G 蛋白偶联受体蛋白水解位点) 结构域内的内源性蛋白水解切割产生两个亚基 (一个大的细胞外 N 末端细胞粘附亚基和一个与 GPCR 的分泌素/降钙素家族) 非共价结合在细胞膜上。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/Calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]

ADGRL3 基因产物(37)

mRNA Protein Name
NM_001322246.3 NP_001309175.1 adhesion G protein-coupled receptor L3 isoform 3 precursor
NM_001322402.3 NP_001309331.1 adhesion G protein-coupled receptor L3 isoform 1 precursor
NM_001371342.1 NP_001358271.1 adhesion G protein-coupled receptor L3 isoform 4 precursor
NM_001371343.2 NP_001358272.1 adhesion G protein-coupled receptor L3 isoform 5 precursor
NM_001371344.2 NP_001358273.1 adhesion G protein-coupled receptor L3 isoform 6 precursor
NM_001371345.2 NP_001358274.1 adhesion G protein-coupled receptor L3 isoform 7 precursor
NM_001371346.2 NP_001358275.1 adhesion G protein-coupled receptor L3 isoform 8 precursor
NM_001387522.1 NP_001374451.1 adhesion G protein-coupled receptor L3 isoform 6 precursor
NM_001387523.1 NP_001374452.1 adhesion G protein-coupled receptor L3 isoform 9 precursor
NM_001387524.1 NP_001374453.1 adhesion G protein-coupled receptor L3 isoform 25 precursor
NM_001387525.1 NP_001374454.1 adhesion G protein-coupled receptor L3 isoform 5 precursor
NM_001387526.1 NP_001374455.1 adhesion G protein-coupled receptor L3 isoform 10 precursor
NM_001387527.1 NP_001374456.1 adhesion G protein-coupled receptor L3 isoform 11 precursor
NM_001387528.1 NP_001374457.1 adhesion G protein-coupled receptor L3 isoform 26 precursor
NM_001387529.1 NP_001374458.1 adhesion G protein-coupled receptor L3 isoform 2 precursor
NM_001387530.1 NP_001374459.1 adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_001387531.1 NP_001374460.1 adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_001387532.1 NP_001374461.1 adhesion G protein-coupled receptor L3 isoform 12 precursor
NM_001387533.1 NP_001374462.1 adhesion G protein-coupled receptor L3 isoform 13 precursor
NM_001387534.1 NP_001374463.1 adhesion G protein-coupled receptor L3 isoform 13 precursor
NM_001387535.1 NP_001374464.1 adhesion G protein-coupled receptor L3 isoform 14 precursor
NM_001387536.1 NP_001374465.1 adhesion G protein-coupled receptor L3 isoform 14 precursor
NM_001387537.1 NP_001374466.1 adhesion G protein-coupled receptor L3 isoform 15 precursor
NM_001387538.1 NP_001374467.1 adhesion G protein-coupled receptor L3 isoform 15 precursor
NM_001387539.1 NP_001374468.1 adhesion G protein-coupled receptor L3 isoform 15 precursor
NM_001387540.1 NP_001374469.1 adhesion G protein-coupled receptor L3 isoform 24 precursor
NM_001387541.1 NP_001374470.1 adhesion G protein-coupled receptor L3 isoform 16
NM_001387542.1 NP_001374471.1 adhesion G protein-coupled receptor L3 isoform 17 precursor
NM_001387543.1 NP_001374472.1 adhesion G protein-coupled receptor L3 isoform 18
NM_001387544.1 NP_001374473.1 adhesion G protein-coupled receptor L3 isoform 18
NM_001387545.1 NP_001374474.1 adhesion G protein-coupled receptor L3 isoform 19 precursor
NM_001387546.1 NP_001374475.1 adhesion G protein-coupled receptor L3 isoform 20 precursor
NM_001387547.1 NP_001374476.1 adhesion G protein-coupled receptor L3 isoform 3 precursor
NM_001387548.1 NP_001374477.1 adhesion G protein-coupled receptor L3 isoform 21 precursor
NM_001387549.1 NP_001374478.1 adhesion G protein-coupled receptor L3 isoform 22 precursor
NM_001387552.1 NP_001374481.1 adhesion G protein-coupled receptor L3 isoform 23 precursor
NM_015236.7 NP_056051.2 adhesion G protein-coupled receptor L3 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
26235030 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26235030 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: 通过直接分析推断
26235030 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
26235030 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADGRL3 蛋白结构

Gal_Lectin

Gal_Lectin: Galactose binding lectin domain (43 - 123)

OLF

OLF: Olfactomedin-like domain (139 - 392)

HRM

HRM: Hormone receptor domain (496 - 552)

(559 - 789)

GPS

GPS: GPCR proteolysis site, GPS, motif (815 - 861)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (876 - 1119)

Latrophilin

Latrophilin: Latrophilin Cytoplasmic C-terminal region (1139 - 1204)

Latrophilin

Latrophilin: Latrophilin Cytoplasmic C-terminal region (1205 - 1469)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1469 a.a.
蛋白主名 其他名称

adhesion G protein-coupled receptor L3

calcium-independent alpha-latrotoxin receptor 3

关联疾病

疾病名称 别名
Sialuria

Sialuria, French Type

French Type Sialuria

Sialuria French Type

Sialic Acid Storage Disease

Sialic Acid Storage Disease, Finnish Type

Infantile Sialic Acid Storage Disease
Oppositional Defiant Disorder

Disorder

Oppositional Defiance

Behavioural Disorder

Oppositional Defiance

Disruptive Mood Dysregulation Disorder
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00363 ADGRL3 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ADGRL3 VGNC VGNC:37652
Felis catus ADGRL3 VGNC VGNC:78449
Mus musculus ADGRL3 MGD MGI:2441950
Rattus norvegicus ADGRL3 RGD RGD:620836
Bos taurus ADGRL3 VGNC VGNC:53686
Macaca mulatta ADGRL3 VGNC VGNC:69659
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