WWC1 - WW and C2 domain containing 1 Gene

中文名称：含 WW 和 C2 域 1

种属: Homo sapiens

同用名: KIBRA; HBEBP3; HBEBP36; MEMRYQTL; PPP1R168

基因 ID: 23286 | 基因类型: protein coding

关于 WWC1

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:168,291,645-168,472,303 (from NCBI)

This gene has 16 transcripts (splice variants), 218 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in salivary gland (RPKM 17.1), kidney (RPKM 16.5) and 17 other tissues.

功能概要

该基因编码的蛋白质是一种细胞质磷蛋白，可与 PRKC-zeta 和动力蛋白轻链-1 相互作用。已发现该基因的等位基因可增强某些个体的记忆力。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2010 年 3 月]

The protein encoded by this gene is a cytoplasmic phosphoprotein that interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that enhance memory in some individuals. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

WWC1 基因产物(3)

mRNA	Protein	Name
NM_001161661.2	NP_001155133.1	protein KIBRA isoform 1
NM_001161662.2	NP_001155134.1	protein KIBRA isoform 2
NM_015238.3	NP_056053.1	protein KIBRA isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables kinase binding	IPI IPI: 通过物理相互作用推断	24682284	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	24682284	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16684779	GOA
enables signaling adaptor activity	IDA IDA: 通过直接分析推断	35429439	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	16684779	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell migration	IDA IDA: 通过直接分析推断	18596123	GOA
involved in hippo signaling	IDA IDA: 通过直接分析推断	35429439	GOA
involved in negative regulation of cell population proliferation	IMP IMP: 通过突变表型推断	24682284	GOA
involved in negative regulation of hippo signaling	IDA IDA: 通过直接分析推断	24682284	GOA
involved in negative regulation of organ growth	IMP IMP: 通过突变表型推断	24682284	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	24682284	GOA
involved in positive regulation of MAPK cascade	IDA IDA: 通过直接分析推断	18190796	GOA
involved in regulation of hippo signaling	IMP IMP: 通过突变表型推断	20159598	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	35429439	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	16684779	GOA
located in cytosol	IDA IDA: 通过直接分析推断	24682284	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16684779	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	18596123	GOA
located in ruffle membrane	IDA IDA: 通过直接分析推断	18190796	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WWC1 蛋白结构

0
200
400
600
800
1000
1113 a.a.

蛋白主名

其他名称

protein KIBRA

HBeAg-binding protein 3

关联疾病

疾病名称

别名

Memory Quantitative Trait Locus

MEMRYQTL

Memory, Enhanced, Qtl

Neurofibromatosis, Type Ii

Neurofibromatosis 2	Neurofibromatosis, Type 2
NF2	Neurofibromatosis Type Ii
Bilateral Acoustic Neurofibromatosis	Banf
Acn	Central Neurofibromatosis
Neurofibromatosis, Central Type	Acoustic Schwannomas, Bilateral
Acoustic Neurinoma, Bilateral	Bilateral Acoustic Neurinoma
Bilateral Acoustic Schwannomas	Familial Acoustic Neuromas

Bjornstad Syndrome

BJS	Pili Torti And Nerve Deafness
Ptd	Pili Torti-Deafness Syndrome
Deafness-Pili Torti-Hypogonadism Syndrome	Deafness And Pili Torti, Bjornstad Type
Pili Torti-Sensorineural Hearing Loss	Björnstad Syndrome
Ptnd	Hearing Loss-Pili Torti-Hypogonadism Syndrome
Bjoernstad Syndrome

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15856	WWC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22361	Wwc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS28883	Wwc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	WWC1	VGNC	VGNC:48439
Felis catus	WWC1	VGNC	VGNC:67096
Bos taurus	WWC1	VGNC	VGNC:36974
Macaca mulatta	WWC1	VGNC	VGNC:79809
Rattus norvegicus	WWC1	RGD	RGD:1308329
Mus musculus	WWC1	MGD	MGI:2388637

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

WWC1 - WW and C2 domain containing 1 Gene

关于 WWC1

功能概要

WWC1 基因产物(3)

WWC1 蛋白结构

关联疾病

直系同源

热门区域

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WWC1 - WW and C2 domain containing 1 Gene

关于 WWC1

功能概要

WWC1 基因产物(3)

WWC1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z