2. Gene
  3. CUX2 - cut like homeobox 2 Gene

CUX2 - cut like homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：切样同源盒 2

种属: Homo sapiens

同用名: CDP2; CUTL2; DEE67; EIEE67

基因 ID: 23316 | 基因类型: protein coding

关于 CUX2

Cytogenetic location: 12q24.11-q24.12 Genomic coordinates (GRCh38): 12:111,034,165-111,350,554 (from NCBI)

This gene has 3 transcripts (splice variants), 225 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in prostate (RPKM 4.9), liver (RPKM 4.6) and 3 other tissues.

功能概要

该基因编码的蛋白质包含三个 CUT 结构域和一个同源结构域；这两个结构域都是 DNA 结合基序。一个相似的基因，其基因产物具有不同的 DNA 结合活性，位于 7 号染色体上。该基因的两个假基因已在 10 号和 4 号染色体上被鉴定。[RefSeq 提供，2013 年 1 月]

This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

CUX2 基因产物(2)

mRNA Protein Name
NM_001370598.1 NP_001357527.1 homeobox protein cut-like 2 isoform 2
NM_015267.4 NP_056082.2 homeobox protein cut-like 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15656993 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cognition IMP
IMP: 通过突变表型推断
15389760 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
15656993 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15656993 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CUX2 蛋白结构

CUT

CUT: CUT domain (550 - 626)

CUT

CUT: CUT domain (889 - 964)

CUT

CUT: CUT domain (1042 - 1120)

Homeobox

Homeobox: Homeobox domain (1169 - 1225)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1486 a.a.
蛋白主名 其他名称

homeobox protein cut-like 2

homeobox protein cux-2

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 67

DEE67

Epileptic Encephalopathy, Early Infantile, 67

Eiee67

Developmental And Epileptic Encephalopathy, 67

Early Infantile Epileptic Encephalopathy 67
Thrombocythemia 1

THCYT1

Thrombocytosis 1

Thrombocythemia, Somatic

Essential Thrombocythemia

Thrombocythemia, Essential
Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential
Lennox-Gastaut Syndrome

Lennox Syndrome

Encephalopathy Of Childhood

Epileptic Encephalopathy Lennox-Gastaut Type

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
Fiedler'S Myocarditis

Isolated Myocarditis

Fiedler Myocarditis

Idiopathic Myocarditis
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03370 CUX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CUX2 VGNC VGNC:82348
Canis familiaris CUX2 VGNC VGNC:39739
Rattus norvegicus CUX2 RGD RGD:1305967
Bos taurus CUX2 VGNC VGNC:27840
Mus musculus CUX2 MGD MGI:107321
Macaca mulatta CUX2 VGNC VGNC:71443
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