2. Gene
  3. FNTB - farnesyltransferase, CAAX box, beta Gene

FNTB - farnesyltransferase, CAAX box, beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：法尼基转移酶，CAAX 盒，β

种属: Homo sapiens

同用名: FPTB

基因 ID: 2342 | 基因类型: protein coding

关于 FNTB

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:64,986,895-65,062,650 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 9.3), brain (RPKM 8.2) and 25 other tissues.

功能概要

启用锌离子结合活性。有助于蛋白质法尼基转移酶活性。参与蛋白质法呢基化。微管相关复合物和蛋白法尼基转移酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation. Part of microtubule associated complex and protein farnesyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

FNTB 基因产物(1)

mRNA Protein Name
NM_002028.4 NP_002019.1 protein farnesyltransferase subunit beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11687658 GOA
contributes to protein farnesyltransferase activity IDA
IDA: 通过直接分析推断
19228685 GOA
enables protein farnesyltransferase activity IDA
IDA: 通过直接分析推断
16893176 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
16893176 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein farnesylation IDA
IDA: 通过直接分析推断
16893176 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of microtubule associated complex IDA
IDA: 通过直接分析推断
19228685 GOA
part of protein farnesyltransferase complex IDA
IDA: 通过直接分析推断
16893176 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FNTB 蛋白结构

SQHop_cyclase_N

SQHop_cyclase_N: Squalene-hopene cyclase N-terminal domain (129 - 240)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (269 - 311)

Prenyltrans

Prenyltrans: Prenyltransferase and squalene oxidase repeat (331 - 373)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
蛋白主名 其他名称

protein farnesyltransferase subunit beta

CAAX farnesyltransferase subunit beta

关联疾病

疾病名称 别名
Myasthenic Syndrome, Congenital, 12

Congenital Myasthenic Syndrome 12

CMS12

Myasthenic Syndrome, Congenital, With Tubular Aggregates 1

Cmsta1

Myasthenia, Congenital, 12, With Tubular Aggregates

Congenital Myasthenia 12 With Tubular Aggregates

Limb-Girdle Myasthenia With Tubular Aggregates

Myasthenia, Congenital, With Tubular Aggregates 1

Myasthenic Syndrome, Congenital, With Tubular Aggregates, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05026 FNTB Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FNTB RGD RGD:620119
Mus musculus FNTB MGD MGI:1861305
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