GTPBP4 - GTP binding protein 4 Gene

中文名称：GTP 结合蛋白 4

种属: Homo sapiens

同用名: NGB; CRFG; NOG1

关于 GTPBP4

功能概要

GTP 结合蛋白是 GTP 酶，作为分子开关发挥作用，可以在两种状态之间切换：激活时，当 GTP 结合时，非活性时，当 GDP 结合时。在这种情况下，“活跃”通常意味着该分子充当触发细胞中其他事件的信号。当细胞外配体与 G 蛋白连接的受体结合时，受体会改变其构象并打开与之相关的三聚体 G 蛋白，使它们排出 GDP 并用 GTP 代替。当 G 蛋白水解其自身结合的 GTP 并将其转化回 GDP 时，开关关闭。但在此之前，活性蛋白有机会从受体扩散开来，并将其信息长时间传递到下游目标。[RefSeq 提供，2008 年 7 月]

GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. 'Active' in this context usually means that the molecule acts as a signal to trigger Other events in the cell. When an extracellular ligand binds to a G-protein-linked receptor, the receptor changes its conformation and switches on the trimeric G proteins that associate with it by causing them to eject their GDP and replace it with GTP. The switch is turned off when the G protein hydrolyzes its own bound GTP, converting it back to GDP. But before that occurs, the active protein has an opportunity to diffuse away from the receptor and deliver its message for a prolonged period to its downstream target. [provided by RefSeq, Jul 2008]