2. Gene
  3. NTSR2 - neurotensin receptor 2 Gene

NTSR2 - neurotensin receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经降压素受体 2

种属: Homo sapiens

同用名: NTR2

基因 ID: 23620 | 基因类型: protein coding

关于 NTSR2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:11,658,178-11,670,195 (from NCBI)

This gene has 1 transcript (splice variant), 79 orthologues and 15 paralogues. Restricted expression toward brain (RPKM 9.3).

功能概要

该基因编码的蛋白质属于激活磷脂酰肌醇-钙第二信使系统的 G 蛋白偶联受体家族。结合和药理学研究表明，该受体结合神经降压素以及已针对神经降压素 NT1 受体描述的其他几种配体。然而，与 NT1 受体不同的是，该基因以高亲和力识别左卡巴斯汀，这是一种组胺 H1 受体拮抗剂，之前显示它与神经降压素竞争大脑中的低亲和力结合位点。这些活动表明该受体可能具有重要的生理学意义，并且可能存在该受体的天然激动剂。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several Other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

NTSR2 基因产物(5)

mRNA Protein Name
XM_005246156.4 XP_005246213.1 neurotensin receptor type 2 isoform X4
XM_017003738.2 XP_016859227.1 neurotensin receptor type 2 isoform X1
NM_012344.4 NP_036476.2 neurotensin receptor type 2
XM_006711877.4 XP_006711940.1 neurotensin receptor type 2 isoform X3
XM_006711876.5 XP_006711939.1 neurotensin receptor type 2 isoform X2

NTSR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (49 - 358)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
蛋白主名 其他名称

neurotensin receptor type 2

NT-R-2

levocabastine-sensitive neurotensin receptor

neurotensin receptor, type 2

关联疾病

疾病名称 别名
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset
Conduct Disorder
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09641 NTSR2 Human Pre-designed siRNA Set A / 否
HY-RS09642 Ntsr2 Mouse Pre-designed siRNA Set A / 否
HY-RS09643 Ntsr2 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NTSR2 MGD MGI:108018
Canis familiaris NTSR2 VGNC VGNC:44015
Rattus norvegicus NTSR2 RGD RGD:70962
Macaca mulatta NTSR2 VGNC VGNC:75545
Bos taurus NTSR2 VGNC VGNC:32313
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z