2. Gene
  3. SPO11 - SPO11 initiator of meiotic double stranded breaks Gene

SPO11 - SPO11 initiator of meiotic double stranded breaks Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：减数分裂双链断裂的 SPO11 启动子

种属: Homo sapiens

同用名: CT35; TOPVIA; SPATA43; TOPOVIA

基因 ID: 23626 | 基因类型: protein coding

关于 SPO11

Cytogenetic location: 20q13.31 Genomic coordinates (GRCh38): 20:57,329,803-57,343,993 (from NCBI)

This gene has 5 transcripts (splice variants) and 197 orthologues. Restricted expression toward testis (RPKM 4.0).

功能概要

减数分裂重组和染色体分离需要在配对的染色体同源物中形成双链断裂 (DSB) 。在酵母减数分裂过程中，减数分裂重组蛋白共价连接到 DSB 的 5' 端，对于 DSB 的形成至关重要。该基因编码的蛋白质在序列和保守特征上与酵母减数分裂重组蛋白质相似。编码的蛋白质属于 TOP6A 蛋白质家族。已发现该基因编码不同亚型的几种转录变体，但仅描述了其中两种的全长性质。[RefSeq 提供，2008 年 7 月]

Meiotic recombination and chromosome segregation require the formation of double-strand breaks (DSBs) in paired chromosome homologs. During meiosis in yeast, a meiotic recombination protein is covalently-linked to the 5' end of DSBs and is essential for the formation of DSBs. The protein encoded by this gene is similar in sequence and conserved features to the yeast meiotic recombination protein. The encoded protein belongs to the TOP6A protein family. Several transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been described. [provided by RefSeq, Jul 2008]

SPO11 基因产物(2)

mRNA Protein Name
NM_012444.3 NP_036576.1 meiotic recombination protein SPO11 isoform a
NM_198265.2 NP_937998.1 meiotic recombination protein SPO11 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
26917763 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPO11 蛋白结构

SPO11_like

SPO11_like: SPO11 homologue (2 - 44)

TP6A_N

TP6A_N: Type IIB DNA topoisomerase (105 - 171)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
蛋白主名 其他名称

meiotic recombination protein SPO11

SPO11 meiotic protein covalently bound to DSB homolog

关联疾病

疾病名称 别名
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Infertility
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2

Aoa2

Ataxia With Oculomotor Apraxia Type 2

Scar1

SCAN2

Ataxia-Oculomotor Apraxia 2

Ataxia-Ocular Apraxia 2

Ataxia-Oculomotor Apraxia Type 2

Scan 2

Spinocerebellar Ataxia With Axonal Neuropathy Type 2

Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly

Scar1, Formerly

Autosomal Recessive Spinocerebellar Ataxia-1

Spinocerebellar Ataxia, Autosomal Recessive, 1

Ataxia-Ocular Apraxia-2

Spinocerebellar Ataxia, Autosomal Recessive 1
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13693 SPO11 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SPO11 VGNC VGNC:35225
Macaca mulatta SPO11 VGNC VGNC:108061
Rattus norvegicus SPO11 RGD RGD:1306454
Mus musculus SPO11 MGD MGI:1349669
Canis familiaris SPO11 VGNC VGNC:46750
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