2. Gene
  3. Adamts5 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) Gene

Adamts5 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: ADMP-2; ASMP-2; ADAMTS1; ADAM-TS5; ADAMTS11; 9530092O11Rik

基因 ID: 23794 | 基因类型: protein coding

关于 Adamts5

功能概要

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]

Adamts5 基因产物(1)

mRNA Protein Name
NM_011782.2 NP_035912.2 A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IMP
IMP: 通过突变表型推断
23233679 MGI
enables extracellular matrix binding IDA
IDA: 通过直接分析推断
24220035 MGI
enables heparin binding IDA
IDA: 通过直接分析推断
24220035 MGI
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
33719441 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aortic valve morphogenesis IMP
IMP: 通过突变表型推断
23531444 MGI
acts upstream of or within defense response to bacterium IGI
IGI: 通过遗传相互作用推断
23684986 MGI
involved in endocardial cushion morphogenesis IGI
IGI: 通过遗传相互作用推断
23531444 MGI
involved in extracellular matrix disassembly IMP
IMP: 通过突变表型推断
23233679 MGI
involved in myoblast fusion IMP
IMP: 通过突变表型推断
23233679 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
28702327 MGI
involved in pulmonary valve morphogenesis IMP
IMP: 通过突变表型推断
23531444 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
24220035 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

A disintegrin and metalloproteinase with thrombospondin motifs 5

aggrecanase-2

implantin

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-137430 Aldumastat Inhibitor 99.36% Phase 2
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114996 ADAMTS-5 Inhibitor Inhibitor 99.59% 否
HY-145061 ADAMTS-5-IN-3 Inhibitor 98.89% 否
HY-P10398 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA 92.55% 否
HY-135710 ADAMTS-5-IN-2 Inhibitor 98.73% 否
HY-P5419A WAAG-3R TFA 99.94% 否
HY-P10468 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 / 否
HY-RS00305 ADAMTS5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-160822 AGG-523 Inhibitor / 否
HY-RS18432 Adamts5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24913 Adamts5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adamts5 NCBI NCBI:11096
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