2. Gene
  3. Gpr68 - G protein-coupled receptor 68 Gene

Gpr68 - G protein-coupled receptor 68 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 68

种属: Mus musculus

同用名: Ogr1

基因 ID: 238377 | 基因类型: protein coding

关于 Gpr68

Chromosome 12: 100,842,941-100,874,457 reverse strand.GRCm39:CM001005.3

This gene has 7 transcripts (splice variants), 197 orthologues, 1 paralogue and is associated with 17 phenotypes. Broad expression in spleen adult (RPKM 5.7), thymus adult (RPKM 5.5) and 2 other tissues.

功能概要

预计该基因编码的蛋白可启动 G 蛋白偶联受体活性。作用于细胞对 pH 值反应的上游或内部；参与细胞对葡萄糖刺激反应的胰岛素分泌的正调节；和骨髓白细胞分化的调节。预测位于质膜中。预计是膜的组成部分。在孕早期表达；初级卵母细胞；和次级卵母细胞。该基因的人类直系同源物与 2A6 型釉质发育不全症有关。与人 GPR68（G 蛋白偶联受体 68）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Acts upstream of or within cellular response to pH; positive regulation of Insulin secretion involved in cellular response to glucose stimulus; and regulation of myeloid leukocyte differentiation. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in early conceptus; primary oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2022]

Gpr68 基因产物(4)

mRNA Protein Name
NM_175493.4 NP_780702.1 ovarian cancer G-protein coupled receptor 1
NM_001177673.1 NP_001171144.1 ovarian cancer G-protein coupled receptor 1
NM_001403314.1 NP_001390243.1 ovarian cancer G-protein coupled receptor 1
NM_001177674.2 NP_001171145.1 ovarian cancer G-protein coupled receptor 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to pH IMP
IMP: 通过突变表型推断
22733973 MGI
acts upstream of insulin secretion IMP
IMP: 通过突变表型推断
22733973 MGI
acts upstream of monocyte differentiation IMP
IMP: 通过突变表型推断
19479052 MGI
acts upstream of or within negative regulation of monocyte differentiation IMP
IMP: 通过突变表型推断
19479052 MGI
acts upstream of osteoclast development IMP
IMP: 通过突变表型推断
19479052 MGI
acts upstream of or within positive regulation of insulin secretion IMP
IMP: 通过突变表型推断
22733973 MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
22733973 MGI
acts upstream of or within positive regulation of osteoclast development IMP
IMP: 通过突变表型推断
19479052 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Gpr68 蛋白结构

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (21 - 48)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (21 - 296)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (55 - 80)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (93 - 123)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (135 - 157)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (181 - 210)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (220 - 250)

7tmA_GPR68_OGR1

7tmA_GPR68_OGR1: cd15367 (264 - 289)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
蛋白主名 其他名称

ovarian cancer G-protein coupled receptor 1

sphingosylphosphorylcholine receptor

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-154954 Ogremorphin Inhibitor 99.60% 否
HY-110279 Ogerin Modulator 99.58% 否
HY-134494 MS48107 99.90% 否
HY-169704 Ogerin analogue 1 Control / 否
HY-105791S Sulazepam-d5 Activator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gpr68 NCBI NCBI:8111
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