2. Gene
  3. Fbln5 - fibulin 5 Gene

Fbln5 - fibulin 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: A55; EVEC; DANCE

基因 ID: 23876 | 基因类型: protein coding

关于 Fbln5

功能概要

Enables Integrin binding activity. Involved in several processes, including elastic fiber assembly; intramembranous bone growth; and regulation of transcription by RNA polymerase II. Acts upstream of or within extracellular matrix organization. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix and elastic fiber. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and skeleton. Used to study cutis laxa. Human ortholog(s) of this gene implicated in age related macular degeneration; autosomal dominant cutis laxa 2; autosomal recessive cutis laxa type IA; and cutis laxa. Orthologous to human FBLN5 (fibulin 5). [provided by Alliance of Genome Resources, Apr 2022]

Fbln5 基因产物(13)

mRNA Protein Name
NM_001361987.2 NP_001348916.1 fibulin-5 isoform 1 precursor
NM_001413776.1 NP_001400705.1 fibulin-5 isoform 3 precursor
NM_001413777.1 NP_001400706.1 fibulin-5 isoform 4 precursor
NM_001413778.1 NP_001400707.1 fibulin-5 isoform 5 precursor
NM_001413779.1 NP_001400708.1 fibulin-5 isoform 6 precursor
NM_001413780.1 NP_001400709.1 fibulin-5 isoform 7 precursor
NM_001413781.1 NP_001400710.1 fibulin-5 isoform 8 precursor
NM_001413782.1 NP_001400711.1 fibulin-5 isoform 9 precursor
NM_001413783.1 NP_001400712.1 fibulin-5 isoform 10 precursor
NM_001413784.1 NP_001400713.1 fibulin-5 isoform 1 precursor
NM_001413785.1 NP_001400714.1 fibulin-5 isoform 12
NM_001413786.1 NP_001400715.1 fibulin-5 isoform 12
NM_011812.5 NP_035942.1 fibulin-5 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IDA
IDA: 通过直接分析推断
11805835 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14745449 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in elastic fiber assembly IMP
IMP: 通过突变表型推断
11805834 MGI
acts upstream of or within extracellular matrix organization IDA
IDA: 通过直接分析推断
18757743 MGI
involved in intramembranous bone growth IMP
IMP: 通过突变表型推断
26399686 MGI
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
17607303 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17607303 MGI
involved in positive regulation of osteoblast proliferation IMP
IMP: 通过突变表型推断
26399686 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17607303 MGI
involved in protein localization to cell surface IMP
IMP: 通过突变表型推断
15528465 MGI
involved in regulation of removal of superoxide radicals IMP
IMP: 通过突变表型推断
15528465 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with collagen-containing extracellular matrix IDA
IDA: 通过直接分析推断
15528465 MGI
colocalizes with elastic fiber IDA
IDA: 通过直接分析推断
11805834 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
14745449 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

fibulin-5

FIBL-5

developmental arteries and neural crest EGF-like protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04774 FBLN5 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22501 Fbln5 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29023 Fbln5 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fbln5 NCBI NCBI:10516
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