2. Gene
  3. Spry2 - sprouty RTK signaling antagonist 2 Gene

Spry2 - sprouty RTK signaling antagonist 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: sprouty2

基因 ID: 24064 | 基因类型: protein coding

关于 Spry2

功能概要

Predicted to enable protein kinase binding activity and protein serine/threonine kinase activator activity. Involved in several processes, including negative regulation of cell differentiation; negative regulation of cell projection organization; and negative regulation of signal transduction. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; lung development; and negative regulation of signal transduction. Located in several cellular components, including cytoskeleton; cytosol; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; future brain; genitourinary system; and limb. Used to study achalasia and intestinal pseudo-obstruction. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human SPRY2 (sprouty RTK signaling antagonist 2). [provided by Alliance of Genome Resources, Apr 2022]

Spry2 基因产物(1)

mRNA Protein Name
NM_011897.3 NP_036027.1 protein sprouty homolog 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function inhibitor activity IMP
IMP: 通过突变表型推断
15962011 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11585837 MGI
enables ubiquitin-protein transferase inhibitor activity IMP
IMP: 通过突变表型推断
15962011 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
21764747 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: 通过突变表型推断
10074434 MGI
acts upstream of or within bud elongation involved in lung branching IGI
IGI: 通过遗传相互作用推断
21764747 MGI
acts upstream of or within cell fate commitment IGI
IGI: 通过遗传相互作用推断
15809037 MGI
acts upstream of or within cell fate commitment IMP
IMP: 通过突变表型推断
15809037 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: 通过表达模式推断
20439489 MGI
acts upstream of or within establishment of mitotic spindle orientation IGI
IGI: 通过遗传相互作用推断
21764747 MGI
acts upstream of fibroblast growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
15809037 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: 通过遗传相互作用推断
15809037 MGI
acts upstream of or within inner ear morphogenesis IMP
IMP: 通过突变表型推断
15809037 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
10074434 MGI
acts upstream of or within lung growth IDA
IDA: 通过直接分析推断
11287183 MGI
acts upstream of or within lung morphogenesis IDA
IDA: 通过直接分析推断
11287183 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
11585837 MGI
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
18508928 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IGI
IGI: 通过遗传相互作用推断
21764747 MGI
acts upstream of or within negative regulation of GTPase activity IDA
IDA: 通过直接分析推断
11585837 MGI
acts upstream of or within negative regulation of MAP kinase activity IDA
IDA: 通过直接分析推断
16339969 MGI
acts upstream of or within negative regulation of Ras protein signal transduction IDA
IDA: 通过直接分析推断
11585837 MGI
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
18070883 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11585837 MGI
involved in negative regulation of cell projection organization IDA
IDA: 通过直接分析推断
18508928 MGI
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: 通过直接分析推断
25576668 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
11585837 MGI
acts upstream of or within negative regulation of fibroblast growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
15809037 MGI
involved in negative regulation of lens fiber cell differentiation IDA
IDA: 通过直接分析推断
29501879 MGI
acts upstream of or within negative regulation of neurotrophin TRK receptor signaling pathway IDA
IDA: 通过直接分析推断
11585837 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: 通过直接分析推断
25576668 MGI
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
15962011 MGI
acts upstream of or within respiratory system development IDA
IDA: 通过直接分析推断
11287183 MGI
acts upstream of or within sensory perception of sound IMP
IMP: 通过突变表型推断
15809037 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoskeleton IDA
IDA: 通过直接分析推断
18508928 MGI
located in cytosol IDA
IDA: 通过直接分析推断
18508928 MGI
located in membrane IDA
IDA: 通过直接分析推断
18508928 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18508928 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein sprouty homolog 2

sprouty homolog 2

spry-2

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13722 SPRY2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22827 Spry2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29342 Spry2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Spry2 NCBI NCBI:10253
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