2. Gene
  3. IFIT5 - interferon induced protein with tetratricopeptide repeats 5 Gene

IFIT5 - interferon induced protein with tetratricopeptide repeats 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：干扰素诱导蛋白与四肽重复 5

种属: Homo sapiens

同用名: P58; RI58; ISG58

基因 ID: 24138 | 基因类型: protein coding

关于 IFIT5

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,414,568-89,420,997 (from NCBI)

This gene has 8 transcripts (splice variants), 527 orthologues and 4 paralogues. Ubiquitous expression in spleen (RPKM 7.8), lung (RPKM 7.7) and 25 other tissues.

功能概要

启用核酸结合活性。参与对病毒的防御反应；病毒基因组复制的负调控；和 I-kappaB 激酶/NF-kappaB 信号的正调控。位于肌动蛋白细胞骨架；细胞的顶端部分；和荷叶边膜。与 IkappaB 激酶复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables nucleic acid binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in actin cytoskeleton; apical part of cell; and ruffle membrane. Colocalizes with IkappaB kinase complex. [provided by Alliance of Genome Resources, Apr 2022]

IFIT5 基因产物(1)

mRNA Protein Name
NM_012420.3 NP_036552.1 interferon-induced protein with tetratricopeptide repeats 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
21642987 GOA
enables RNA cap binding IDA
IDA: 通过直接分析推断
25092312 GOA
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
23774268 GOA
enables poly(U) RNA binding IDA
IDA: 通过直接分析推断
25092312 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26334375 GOA
enables single-stranded RNA binding IDA
IDA: 通过直接分析推断
23334420 GOA
enables tRNA binding IDA
IDA: 通过直接分析推断
23317505 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IMP
IMP: 通过突变表型推断
23334420 GOA
involved in negative regulation of viral genome replication IDA
IDA: 通过直接分析推断
23774268 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
26334375 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of IkappaB kinase complex IMP
IMP: 通过突变表型推断
26334375 GOA
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
23317505 GOA
located in apical part of cell IDA
IDA: 通过直接分析推断
23317505 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
23317505 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IFIT5 蛋白结构

TPR_12

TPR_12: Tetratricopeptide repeat (52 - 118)

TPR_2

TPR_2: Tetratricopeptide repeat (154 - 173)

TPR_2

TPR_2: Tetratricopeptide repeat (250 - 281)

TPR_11

TPR_11: TPR repeat (338 - 406)

TPR_1

TPR_1: Tetratricopeptide repeat (437 - 468)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
蛋白主名 其他名称

interferon-induced protein with tetratricopeptide repeats 5

IFIT-5

关联疾病

疾病名称 别名
Zika Virus Congenital Syndrome

Zikv Congenital Infection
Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06564 IFIT5 Human Pre-designed siRNA Set A Pre-designed Set / 否
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