2. Gene
  3. Akr1b1 - aldo-keto reductase family 1 member B1 Gene

Akr1b1 - aldo-keto reductase family 1 member B1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Alr; Aldr1; ALDRED; Akr1b3; Akr1b4; ALR-P-I; RATALDRED

基因 ID: 24192 | 基因类型: protein coding

关于 Akr1b1

功能概要

Enables alditol:NADP+ 1-oxidoreductase activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]

Akr1b1 基因产物(1)

mRNA Protein Name
NM_012498.1 NP_036630.1 aldo-keto reductase family 1 member B1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aldose reductase (NADPH) activity IDA
IDA: 通过直接分析推断
2114645 RGD
enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity IDA
IDA: 通过直接分析推断
8407226 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to methylglyoxal IDA
IDA: 通过直接分析推断
12604218 RGD
involved in cellular response to peptide IEP
IEP: 通过表达模式推断
17490626 RGD
involved in inner medullary collecting duct development IDA
IDA: 通过直接分析推断
1401064 RGD
involved in maternal process involved in female pregnancy IEP
IEP: 通过表达模式推断
2121099 RGD
involved in monosaccharide metabolic process IDA
IDA: 通过直接分析推断
2119895 RGD
involved in norepinephrine metabolic process IDA
IDA: 通过直接分析推断
10424772 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: 通过突变表型推断
15746188 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
16648138 RGD
involved in response to thyroid hormone IEP
IEP: 通过表达模式推断
19422879 RGD
involved in sorbitol biosynthetic process IMP
IMP: 通过突变表型推断
6690344 RGD
involved in stress-activated protein kinase signaling cascade IMP
IMP: 通过突变表型推断
16669970 RGD
involved in tissue homeostasis IMP
IMP: 通过突变表型推断
21376710 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Schmidt-Lanterman incisure IDA
IDA: 通过直接分析推断
1650113 RGD
located in Schwann cell microvillus IDA
IDA: 通过直接分析推断
1650113 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
16332428 RGD
located in mast cell granule IDA
IDA: 通过直接分析推断
1650113 RGD
located in paranodal junction IDA
IDA: 通过直接分析推断
1650113 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
8150024 RGD
located in plasma membrane bounded cell projection cytoplasm IDA
IDA: 通过直接分析推断
8150024 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aldo-keto reductase family 1 member B1

AR

Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)

aldo-keto reductase family 1 member B

aldose reductase

Akr1b1 抗体

目录号 产品名 应用 反应物种
HY-P85558 Aldose Reductase Antibody (YA5250) WB Human, Mouse, Rat

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-106697 Ponalrestat Inhibitor 99.51% 否
HY-133708 β-Glucogallin 99.82% 否
HY-N0310 Soyasaponin Bb 99.88% 否
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / 否
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / 否
HY-175331 ALR2-IN-7 Inhibitor / 否
HY-175639 ALR2-IN-8 Inhibitor / 否
HY-176719 AKR1B1/STAT3/SLC7A11-regulator-1 / 否
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17235 Akr1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23688 Akr1b1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Akr1b1 NCBI NCBI:231
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