2. Gene
  3. Atp1a1 - ATPase Na+/K+ transporting subunit alpha 1 Gene

Atp1a1 - ATPase Na+/K+ transporting subunit alpha 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Nkaa1b

基因 ID: 24211 | 基因类型: protein coding

关于 Atp1a1

功能概要

Enables several functions, including adenyl ribonucleotide binding activity; alkali metal ion binding activity; and ankyrin binding activity. Involved in several processes, including cellular response to mechanical stimulus; inorganic cation transmembrane transport; and membrane hyperpolarization. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Used to study hypertension. Biomarker of hyperhomocysteinemia and sensorineural hearing loss. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a1 基因产物(1)

mRNA Protein Name
NM_012504.1 NP_036636.1 sodium/potassium-transporting ATPase subunit alpha-1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP binding IDA
IDA: 通过直接分析推断
12730684 RGD
enables ATP binding IDA
IDA: 通过直接分析推断
12730684 RGD
enables P-type sodium:potassium-exchanging transporter activity IDA
IDA: 通过直接分析推断
12531906 RGD
enables ankyrin binding IPI
IPI: 通过物理相互作用推断
8159688 RGD
enables phosphatidylinositol 3-kinase binding IPI
IPI: 通过物理相互作用推断
17728397 RGD
enables potassium ion binding IDA
IDA: 通过直接分析推断
16269407 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12093728 RGD
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
16269407 RGD
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
28787093 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
17939993 RGD
enables protein-folding chaperone binding IDA
IDA: 通过直接分析推断
18768923 RGD
enables sodium ion binding IDA
IDA: 通过直接分析推断
16269407 RGD
enables sodium ion binding IMP
IMP: 通过突变表型推断
18075585 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to mechanical stimulus IDA
IDA: 通过直接分析推断
17458903 RGD
involved in membrane hyperpolarization IMP
IMP: 通过突变表型推断
17001300 RGD
involved in potassium ion import across plasma membrane IDA
IDA: 通过直接分析推断
12531906 RGD
involved in potassium ion transport IDA
IDA: 通过直接分析推断
12093728 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: 通过突变表型推断
15629895 RGD
involved in regulation of sodium ion transport IDA
IDA: 通过直接分析推断
17939993 RGD
involved in sodium ion export across plasma membrane IDA
IDA: 通过直接分析推断
18075585 RGD
involved in sodium ion transport IDA
IDA: 通过直接分析推断
12093728 RGD
involved in transmembrane transport IDA
IDA: 通过直接分析推断
18075585 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
18768923 RGD
located in T-tubule IDA
IDA: 通过直接分析推断
17442282 RGD
located in basolateral plasma membrane IMP
IMP: 通过突变表型推断
16914892 RGD
located in caveola IDA
IDA: 通过直接分析推断
16624992 RGD
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
18768923 RGD
located in endosome IDA
IDA: 通过直接分析推断
16893515 RGD
located in intercalated disc IDA
IDA: 通过直接分析推断
17442282 RGD
located in membrane IDA
IDA: 通过直接分析推断
28787093 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
18768923 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
17442282 RGD
part of sodium:potassium-exchanging ATPase complex IDA
IDA: 通过直接分析推断
12093728 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sodium/potassium-transporting ATPase subunit alpha-1

ATPase, Na+/K+ transporting, alpha 1 polypeptide

ATPase, Na+K+ transporting, alpha 1

Na(+)/K(+) ATPase alpha-1 subunit

sodium pump subunit alpha-1

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-12283 Rostafuroxin 99.03% Phase 2
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2657 Verucopeptin Inhibitor ≥99.0% 否
HY-P1565A Transdermal Peptide Disulfide TFA Inhibitor 98.86% 否
HY-RS01182 ATP1A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-P1565 Transdermal Peptide Disulfide Inhibitor / 否
HY-P4856 pTH-Related Protein (1-40) (human, mouse, rat) Activator / 否
HY-RS01184 ATP1A3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01185 ATP1A4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS01186 ATP1B1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16918 Atp1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21097 Atp1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23361 Atp1a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27615 Atp1b1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atp1a1 NCBI NCBI:476
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