2. Gene
  3. Got1 - glutamic-oxaloacetic transaminase 1 Gene

Got1 - glutamic-oxaloacetic transaminase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: AAT1; ASAT; cCAT; Aspat; Gaspat; cAspAT

基因 ID: 24401 | 基因类型: protein coding

关于 Got1

功能概要

Enables L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine:2-oxoglutarate aminotransferase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and ion homeostasis. Located in axon terminus; cytosol; and lysosome. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]

Got1 基因产物(1)

mRNA Protein Name
NM_012571.2 NP_036703.2 aspartate aminotransferase, cytoplasmic
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
IDA: 通过直接分析推断
2837211 RGD
enables L-aspartate:2-oxoglutarate aminotransferase activity IMP
IMP: 通过突变表型推断
7562489 RGD
enables L-cysteine transaminase activity IDA
IDA: 通过直接分析推断
7113743 RGD
enables carboxylic acid binding IDA
IDA: 通过直接分析推断
2837211 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-glutamate biosynthetic process IDA
IDA: 通过直接分析推断
16489927 RGD
involved in aspartate metabolic process IDA
IDA: 通过直接分析推断
2837211 RGD
involved in cellular response to mechanical stimulus IDA
IDA: 通过直接分析推断
26880260 RGD
involved in dicarboxylic acid metabolic process IDA
IDA: 通过直接分析推断
2837211 RGD
involved in dicarboxylic acid metabolic process IMP
IMP: 通过突变表型推断
7562489 RGD
involved in glycerol biosynthetic process IDA
IDA: 通过直接分析推断
17545671 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
26880260 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
29215467 RGD
involved in negative regulation of mitochondrial depolarization IMP
IMP: 通过突变表型推断
29215467 RGD
involved in oxaloacetate metabolic process IDA
IDA: 通过直接分析推断
16489927 RGD
involved in positive regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
26880260 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
29101047 RGD
involved in response to carbohydrate IEP
IEP: 通过表达模式推断
29101047 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
25451275 RGD
involved in response to transition metal nanoparticle IDA
IDA: 通过直接分析推断
28962237 RGD
involved in transdifferentiation IMP
IMP: 通过突变表型推断
28797105 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon terminus IDA
IDA: 通过直接分析推断
2364283 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

aspartate aminotransferase, cytoplasmic

aspartate aminotransferase 1

cysteine aminotransferase, cytoplasmic

cysteine transaminase, cytoplasmic

cytosolic aspartate aminotransferase

glutamate oxaloacetate transaminase 1, soluble

glutamic-oxaloacetic transaminase 1, soluble

transaminase A

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0091 Adapalene 99.98% 是
HY-B0091R Adapalene (Standard) / 否
HY-B0091A Adapalene sodium salt / 否
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-122723 GOT1 inhibitor-1 Inhibitor 99.45% 否
HY-160818 MC3138 Activator 99.27% 否
HY-124825 iGOT1-01 99.77% 否
HY-N6237 Aspulvinone O ≥96.0% 否
HY-RS05605 GOT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-B0091S Adapalene-d3 / 否
HY-RS05596 GOLT1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16967 Got1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS23410 Got1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Got1 NCBI NCBI:2805
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