2. Gene
  3. Nppa - natriuretic peptide A Gene

Nppa - natriuretic peptide A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: ANF; ANP; CDD; Pnd; RATANF

基因 ID: 24602 | 基因类型: protein coding

关于 Nppa

功能概要

Enables hormone activity. Involved in several processes, including cGMP biosynthetic process; cellular response to mechanical stimulus; and regulation of ion transport. Acts upstream of or within receptor guanylyl cyclase signaling pathway. Located in several cellular components, including brush border; mast cell granule; and perinuclear region of cytoplasm. Used to study congestive heart failure; pulmonary hypertension; and ureteral obstruction. Biomarker of acute kidney failure; artery disease (multiple); hypertrophic cardiomyopathy; and nephrosis. Human ortholog(s) of this gene implicated in artery disease (multiple); heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A). [provided by Alliance of Genome Resources, Apr 2022]

Nppa 基因产物(1)

mRNA Protein Name
NM_012612.2 NP_036744.1 natriuretic peptides A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone activity IDA
IDA: 通过直接分析推断
7552344 RGD
enables signaling receptor binding IDA
IDA: 通过直接分析推断
11751587 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cGMP biosynthetic process IMP
IMP: 通过突变表型推断
10559136 RGD
involved in cGMP-mediated signaling IDA
IDA: 通过直接分析推断
12217425 RGD
involved in cell growth involved in cardiac muscle cell development IEP
IEP: 通过表达模式推断
7657802 RGD
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
27249171 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
27249171 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
23617620 RGD
involved in negative regulation of cell growth IMP
IMP: 通过突变表型推断
16010968 RGD
involved in negative regulation of collecting lymphatic vessel constriction IDA
IDA: 通过直接分析推断
23897233 RGD
involved in negative regulation of systemic arterial blood pressure IDA
IDA: 通过直接分析推断
2136863 RGD
involved in positive regulation of cGMP-mediated signaling IDA
IDA: 通过直接分析推断
7552344 RGD
involved in positive regulation of delayed rectifier potassium channel activity IDA
IDA: 通过直接分析推断
8301666 RGD
involved in positive regulation of histamine secretion by mast cell IDA
IDA: 通过直接分析推断
9663691 RGD
involved in positive regulation of potassium ion export across plasma membrane IDA
IDA: 通过直接分析推断
8301666 RGD
acts upstream of or within receptor guanylyl cyclase signaling pathway IDA
IDA: 通过直接分析推断
17951249 RGD
involved in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IDA
IDA: 通过直接分析推断
8301666 RGD
involved in regulation of high voltage-gated calcium channel activity IDA
IDA: 通过直接分析推断
8301666 RGD
involved in response to 3-methylcholanthrene IEP
IEP: 通过表达模式推断
19889059 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
2136863 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
16828931 RGD
involved in synaptic signaling via neuropeptide EXP
EXP: 通过实验结果推断
24060848 RGD
involved in synaptic signaling via neuropeptide IDA
IDA: 通过直接分析推断
24060848 RGD
involved in synaptic signaling via neuropeptide IMP
IMP: 通过突变表型推断
24060848 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in brush border IDA
IDA: 通过直接分析推断
1372667 RGD
is active in glycinergic synapse EXP
EXP: 通过实验结果推断
24060848 RGD
is active in glycinergic synapse IDA
IDA: 通过直接分析推断
24060848 RGD
is active in glycinergic synapse IMP
IMP: 通过突变表型推断
24060848 RGD
located in mast cell granule IDA
IDA: 通过直接分析推断
16246270 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16270351 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

natriuretic peptides A

Natriuretic peptide precursor A (pronatriodilatin, also Anf, Pnd)

atrial natriuretic factor prohormone

atrial natriuretic peptide prohormone

atriopeptigen

cardiodilatin

natriuretic peptide precursor type A

preproANF

preproANP

preproCDD-ANF

prepro

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09494 NPPA Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19624 Nppa Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26119 Nppa Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nppa NCBI NCBI:4878
Canis familiaris Nppa NCBI NCBI:608289
Macaca fascicularis Nppa NCBI NCBI:102116318
Mus musculus Nppa NCBI NCBI:230899
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