2. Gene
  3. Optn - optineurin Gene

Optn - optineurin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Fip2

基因 ID: 246294 | 基因类型: protein coding

关于 Optn

功能概要

Enables TFIIIA-class transcription factor binding activity; identical protein binding activity; and ubiquitin binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to tumor necrosis factor; and regulation of neuron apoptotic process. Located in several cellular components, including axon; neuronal cell body; and perinuclear region of cytoplasm. Colocalizes with Golgi apparatus. Biomarker of Parkinson's disease; bladder neck obstruction; proteinuria; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Orthologous to human OPTN (optineurin). [provided by Alliance of Genome Resources, Apr 2022]

Optn 基因产物(1)

mRNA Protein Name
NM_145081.4 NP_659549.3 optineurin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables TFIIIA-class transcription factor binding IPI
IPI: 通过物理相互作用推断
10756201 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20161783 RGD
enables ubiquitin binding IDA
IDA: 通过直接分析推断
21059646 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Golgi organization IMP
IMP: 通过突变表型推断
15837803 RGD
involved in cellular response to L-glutamate IEP
IEP: 通过表达模式推断
28761318 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: 通过表达模式推断
28776281 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: 通过表达模式推断
17663725 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
28776281 RGD
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
28776281 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
22194658 RGD
involved in neural retina development IEP
IEP: 通过表达模式推断
17687037 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
22194658 RGD
involved in positive regulation of cytokine production IMP
IMP: 通过突变表型推断
28776281 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
22194658 RGD
involved in positive regulation of neural precursor cell proliferation IMP
IMP: 通过突变表型推断
22194658 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
25385380 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
15837803 RGD
located in axon IDA
IDA: 通过直接分析推断
28761318 RGD
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
15837803 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
28761318 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
28776281 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

optineurin

14.7K-interacting protein 2

FIP-2-like protein

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09809 OPTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18146 Optn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24621 Optn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Optn NCBI NCBI:10133
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