2. Gene
  3. Hnf1a - HNF1 homeobox A Gene

Hnf1a - HNF1 homeobox A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: HNF1; Lfb1; Tcf1; LF-B1

基因 ID: 24817 | 基因类型: protein coding

关于 Hnf1a

功能概要

Enables DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and transcription coactivator binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated. Located in chromatin and nucleus. Part of protein-containing complex. Used to study hepatocellular adenoma and hepatocellular carcinoma. Biomarker of extrahepatic cholestasis and kidney disease. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); liver disease (multiple); and renal cell carcinoma. Orthologous to human HNF1A (HNF1 homeobox A). [provided by Alliance of Genome Resources, Apr 2022]

Hnf1a 基因产物(1)

mRNA Protein Name
NM_012669.1 NP_036801.1 hepatocyte nuclear factor 1-alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
1763325 RGD
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
20735474 RGD
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
1763325 RGD
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
14561216 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
12753154 RGD
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
15598887 RGD
enables transcription coregulator binding IPI
IPI: 通过物理相互作用推断
15598887 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of protein kinase activity IMP
IMP: 通过突变表型推断
20841353 RGD
involved in apoptotic nuclear changes IMP
IMP: 通过突变表型推断
20841353 RGD
involved in cellular response to L-leucine IMP
IMP: 通过突变表型推断
21874357 RGD
involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
20841353 RGD
involved in cellular response to rapamycin IMP
IMP: 通过突变表型推断
21874357 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
20841353 RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
21874357 RGD
involved in negative regulation of miRNA processing IMP
IMP: 通过突变表型推断
23674172 RGD
involved in negative regulation of peptidyl-threonine phosphorylation IMP
IMP: 通过突变表型推断
20841353 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7937157 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: 通过突变表型推断
20841353 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
20841353 RGD
involved in positive regulation of insulin secretion IEP
IEP: 通过表达模式推断
10944108 RGD
involved in positive regulation of mitochondrial membrane potential IMP
IMP: 通过突变表型推断
10944108 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
21874357 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
21874357 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
7937157 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
15598887 RGD
involved in regulation of NADP metabolic process IMP
IMP: 通过突变表型推断
20841353 RGD
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
14561216 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
15598887 RGD
located in nucleus IDA
IDA: 通过直接分析推断
1763325 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
15598887 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepatocyte nuclear factor 1-alpha

HNF-1-alpha

HNF-1A

LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1

TCF-1

Transcription factor 1, hepatic

albumin proximal factor

hepatic nuclear factor 1

hepatic nuclear factor-1-alpha

liver-specific transcription factor L

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06255 HNF1A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-174669 Human HNF1A mRNA / 否
HY-RS19690 Hnf1a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26185 Hnf1a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hnf1a NCBI NCBI:6927
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