2. Gene
  3. Dmd - dystrophin Gene

Dmd - dystrophin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: DNADMD1

基因 ID: 24907 | 基因类型: protein coding

关于 Dmd

功能概要

Enables several functions, including PDZ domain binding activity; Integrin binding activity; and lamin binding activity. Involved in several processes, including nervous system development; regulation of neuron differentiation; and response to denervation involved in regulation of muscle adaptation. Located in several cellular components, including mitochondrial membrane; neurofilament; and secretory vesicle. Part of dystrophin-associated glycoprotein complex. Used to study Duchenne muscular dystrophy; brain edema; and dilated cardiomyopathy. Biomarker of muscular atrophy; retinal degeneration; and status epilepticus. Human ortholog(s) of this gene implicated in cognitive disorder; dilated cardiomyopathy (multiple); intellectual disability; and muscular dystrophy (multiple). Orthologous to human DMD (Dystrophin). [provided by Alliance of Genome Resources, Apr 2022]

Dmd 基因产物(4)

mRNA Protein Name
NM_001005244.2 NP_001005244.1 dystrophin isoform Dp71ab
NM_001005246.1 NP_001005246.1 dystrophin isoform Dp71c
NM_001370876.1 NP_001357805.1 dystrophin isoform 1
NM_012698.3 NP_036830.2 dystrophin isoform Dp71a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
15024025 RGD
enables actin binding IDA
IDA: 通过直接分析推断
10984432 RGD
enables integrin binding IPI
IPI: 通过物理相互作用推断
18677563 RGD
enables lamin binding IPI
IPI: 通过物理相互作用推断
21886794 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10545507 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
15247274 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell differentiation IEP
IEP: 通过表达模式推断
22008482 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
1454857 RGD
involved in muscle cell differentiation IEP
IEP: 通过表达模式推断
19903098 RGD
involved in negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
21668890 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
8858620 RGD
involved in neuron projection morphogenesis IMP
IMP: 通过突变表型推断
15706226 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
21886794 RGD
involved in positive regulation of neuron differentiation IMP
IMP: 通过突变表型推断
15149856 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
15149856 RGD
involved in regulation of cellular response to growth factor stimulus IMP
IMP: 通过突变表型推断
15149856 RGD
involved in response to denervation involved in regulation of muscle adaptation IEP
IEP: 通过表达模式推断
8906620 RGD
involved in skeletal muscle tissue regeneration IEP
IEP: 通过表达模式推断
12086334 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in astrocyte projection IDA
IDA: 通过直接分析推断
10411999 RGD
located in axon IDA
IDA: 通过直接分析推断
9858364 RGD
located in cell projection IDA
IDA: 通过直接分析推断
11368101 RGD
part of dystrophin-associated glycoprotein complex IDA
IDA: 通过直接分析推断
15247274 RGD
located in lamellipodium IDA
IDA: 通过直接分析推断
11368101 RGD
located in matrix side of mitochondrial inner membrane IDA
IDA: 通过直接分析推断
10913331 RGD
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
10411999 RGD
located in myofibril IDA
IDA: 通过直接分析推断
12890920 RGD
located in neurofilament IDA
IDA: 通过直接分析推断
11326752 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
10359335 RGD
located in nucleus IDA
IDA: 通过直接分析推断
15149856 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11368101 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
10545507 RGD
located in ribosome IDA
IDA: 通过直接分析推断
10411999 RGD
located in sarcolemma IDA
IDA: 通过直接分析推断
12037582 RGD
located in secretory granule IDA
IDA: 通过直接分析推断
9858364 RGD
located in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
1454857 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dystrophin

apodystrophin-3

apodystrophin-I

dystrophin, muscular dystrophy

dystrophin-related

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14842 Givinostat Inhibitor 98.67% 是
HY-132611A Golodirsen sodium Modulator 92.00% 否
HY-132611 Golodirsen 92.00% 否
Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-108753 Eteplirsen 98.50% Phase 3
HY-145724 Drisapersen Inhibitor 96.05% Phase 3
HY-17614 Ezutromid 98.87% Phase 2
HY-134377 Bocidelpar Modulator 98.08% Phase 2
HY-127137 Adenylosuccinic acid 95.0% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99857 Domagrozumab Inhibitor 96.34% Phase 2
Pre-clinical Phase
生物活性分子 (22)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-152182 ML-SA5 Agonist 99.69% 否
HY-147332 TCL053 99.92% 否
HY-132586A Viltolarsen sodium Modulator 95.25% 否
HY-15898 Y-320 99.03% 否
HY-101459 RTC13 98.01% 否
HY-132586 Viltolarsen Modulator 95.25% 否
HY-127137A Adenylosuccinic acid tetraammonium 99.62% 否
HY-122631 TG693 99.95% 否
HY-114739 MA-0204 Modulator 99.31% 否
HY-139972 PROTAC(H-PGDS)-7 99.42% 否
HY-153369 BAY-747 Activator / 否
HY-150237 FITC-labeled Drisapersen sodium Inhibitor 92.99% 否
HY-RS03823 DMD Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-122588A Negamycin hydrochloride / 否
HY-133754 MI-1063 MDM2 Inhibitor / 否
HY-14931 Naproxcinod Inhibitor / 否
HY-150077 Utrophin modulator 1 / 否
HY-150078 OX01914 / 否
HY-177659 Rimigorsen Inhibitor / 否
HY-177659A Rimigorsen sodium Inhibitor / 否
HY-RS18019 Dmd Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24492 Dmd Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dmd NCBI NCBI:1756
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z