2. Gene
  3. Ptn - pleiotrophin Gene

Ptn - pleiotrophin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: HARP; Hbnf

基因 ID: 24924 | 基因类型: protein coding

关于 Ptn

功能概要

Enables several functions, including glycosaminoglycan binding activity; growth factor activity; and syndecan binding activity. Involved in several processes, including animal organ development; nervous system development; and regulation of epithelial cell proliferation. Located in several cellular components, including basement membrane; neuromuscular junction; and perinuclear region of cytoplasm. Is active in postsynapse and presynapse. Used to study Parkinson's disease. Biomarker of several diseases, including extrahepatic cholestasis; liver cirrhosis; sciatic neuropathy; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in adrenal carcinoma. Orthologous to human PTN (pleiotrophin). [provided by Alliance of Genome Resources, Apr 2022]

Ptn 基因产物(1)

mRNA Protein Name
NM_017066.3 NP_058762.1 pleiotrophin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chondroitin sulfate proteoglycan binding IPI
IPI: 通过物理相互作用推断
20369290 RGD
enables glycosaminoglycan binding IDA
IDA: 通过直接分析推断
7925491 RGD
enables growth factor activity IDA
IDA: 通过直接分析推断
16226713 RGD
enables heparan sulfate binding IPI
IPI: 通过物理相互作用推断
8567685 RGD
enables heparin binding IDA
IDA: 通过直接分析推断
16226713 RGD
enables heparin binding IPI
IPI: 通过物理相互作用推断
8567685 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
8175719 RGD
enables proteoglycan binding IPI
IPI: 通过物理相互作用推断
8702927 RGD
enables syndecan binding IPI
IPI: 通过物理相互作用推断
9817766 RGD
enables vascular endothelial growth factor binding IPI
IPI: 通过物理相互作用推断
17881084 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to UV IEP
IEP: 通过表达模式推断
17925408 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
16226713 RGD
involved in cellular response to organic cyclic compound IEP
IEP: 通过表达模式推断
12057922 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: 通过表达模式推断
16226713 RGD
involved in cellular response to vitamin D IEP
IEP: 通过表达模式推断
21153232 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
8653419 RGD
involved in dendrite regeneration IDA
IDA: 通过直接分析推断
27671118 RGD
involved in endothelial cell differentiation IEP
IEP: 通过表达模式推断
20830586 RGD
involved in estrous cycle IEP
IEP: 通过表达模式推断
9846168 RGD
involved in heart development IEP
IEP: 通过表达模式推断
17925408 RGD
involved in hindbrain development IEP
IEP: 通过表达模式推断
9749725 RGD
involved in learning IEP
IEP: 通过表达模式推断
24069387 RGD
involved in liver development IEP
IEP: 通过表达模式推断
12057922 RGD
involved in long-term synaptic potentiation IEP
IEP: 通过表达模式推断
8904779 RGD
involved in lung development IEP
IEP: 通过表达模式推断
2270483 RGD
involved in negative regulation of angiogenesis IMP
IMP: 通过突变表型推断
17881084 RGD
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
17881084 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: 通过直接分析推断
8812110 RGD
involved in negative regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
17881084 RGD
involved in negative regulation of membrane potential IDA
IDA: 通过直接分析推断
9753126 RGD
involved in negative regulation of mesenchymal cell proliferation IDA
IDA: 通过直接分析推断
8812110 RGD
involved in negative regulation of neuromuscular junction development IDA
IDA: 通过直接分析推断
7722643 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
17925408 RGD
involved in positive regulation of axon regeneration IDA
IDA: 通过直接分析推断
27671118 RGD
involved in positive regulation of cell-substrate adhesion IDA
IDA: 通过直接分析推断
7925491 RGD
involved in positive regulation of hepatocyte proliferation IDA
IDA: 通过直接分析推断
16226713 RGD
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
7955315 RGD
involved in positive regulation of ossification IMP
IMP: 通过突变表型推断
9817766 RGD
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: 通过直接分析推断
7722643 RGD
involved in regulation of cell shape IMP
IMP: 通过突变表型推断
17881084 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
21688311 RGD
involved in response to ciliary neurotrophic factor IEP
IEP: 通过表达模式推断
16914133 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
9846168 RGD
involved in response to kainic acid IEP
IEP: 通过表达模式推断
7477935 RGD
involved in response to nerve growth factor IEP
IEP: 通过表达模式推断
16914133 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
9846168 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
7970205 RGD
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
8453763 RGD
involved in retinal rod cell differentiation IMP
IMP: 通过突变表型推断
16914133 RGD
involved in rod bipolar cell differentiation IEP
IEP: 通过表达模式推断
16914133 RGD
involved in spinal cord development IEP
IEP: 通过表达模式推断
8453763 RGD
involved in thalamus development IEP
IEP: 通过表达模式推断
10051750 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
9990431 RGD
located in cell surface IDA
IDA: 通过直接分析推断
8812110 RGD
located in extracellular region IDA
IDA: 通过直接分析推断
12057922 RGD
located in neuromuscular junction IDA
IDA: 通过直接分析推断
8812110 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16226713 RGD
is active in postsynapse IDA
IDA: 通过直接分析推断
7955321 RGD
is active in presynapse IDA
IDA: 通过直接分析推断
7955321 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

pleiotrophin

HB-GAM

HBBM

HBGF-8

OSF-1

Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)

heparin affine regulatory peptide

heparin binding factor

heparin-binding brain mitogen

heparin-binding growth factor 8

heparin-binding growth-associated molecule

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11407 PTN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17103 Ptn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23547 Ptn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptn NCBI NCBI:5764
Mus musculus Ptn NCBI NCBI:19242
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z