1. Gene
  2. ALPP - alkaline phosphatase, placental Gene

ALPP - alkaline phosphatase, placental Gene

中文名称:碱性磷酸酶,胎盘

种属: Homo sapiens

同用名: ALP; IAP; ALPI; PALP; PLAP; PLAP-1

基因 ID: 250 | 基因类型: protein coding

关于 ALPP

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,378,751-232,382,889 (from NCBI)

This gene has 3 transcripts (splice variants), 363 orthologues and 3 paralogues. Restricted expression toward placenta (RPKM 36.6).

功能概要

该基因编码的蛋白质是一种碱性磷酸酶,一种催化磷酸单酯水解的金属酶。它属于由四种碱性磷酸酶同工酶组成的多基因家族。该酶作为同源二聚体发挥作用,并具有包含一个镁离子和两个锌离子的催化位点,这是其酶促功能所必需的。这种酶的主要来源之一是肝脏,因此,它是不同临床情况下肝损伤的几个指标之一。在孕妇中,该蛋白主要在胎盘和子宫内膜组织中表达,但在卵巢腺癌、浆液性囊腺癌和其他卵巢癌细胞中检测到强烈的异位表达。[RefSeq 提供,2020 年 8 月]

The protein encoded by this gene is an Alkaline Phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four Alkaline Phosphatase isoenzymes. The Enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this Enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian Cancer cells. [provided by RefSeq, Aug 2020]

ALPP 基因产物(1)

mRNA Protein Name
NM_001632.5 NP_001623.3 alkaline phosphatase, placental type preproprotein

ALPP 蛋白结构

Alk_phosphatase

Alk_phosphatase: Alkaline phosphatase (55 - 490)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
蛋白主名 其他名称

alkaline phosphatase, placental type

Intestinal alkaline phosphatase

重组 ALPP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7487 Alkaline Phosphatase/ALPP Protein, Human (HEK293, His) P05187 (I23-D506) ≥95%
HY-P75515 Alkaline Phosphatase/ALPP Protein, Human (P.pastoris, His) P05187 (I23-D506) ≥95%
HY-P7487A Alkaline Phosphatase/ALPP Protein, Human (HEK293, C-His) P05187 (I23-D506) ≥95%

关联疾病

疾病名称 别名
Obstructive Jaundice

Jaundice, Obstructive

Cholestatic Jaundice

Cholestatic Jaundice Syndrome

Obstructive Hyperbilirubinemia

Jaundice Obstructive

Jaundice Cholestatic

Hypophosphatasia

Phosphoethanolaminuria

Childhood Hypophosphatasia

Deficiency Of Alkaline Phosphatase

Hypophospatasia, Childhood

Hypophosphatasia Mild

Phosphoethanol-Aminuria

Rathburn Disease

Hpp

Rathbun Disease

Hypophosphatasia, Childhood

Infantile Hypophosphatasia

Seminoma

Seminoma, Pure

Hepatic Tuberculosis

Tuberculosis, Hepatic

Tuberculosis Of Liver

Tuberculosis Hepatic

Germinoma
Germ Cell Cancer

Malignant Germ Cell Tumor

Neoplasms, Germ Cell And Embryonal

Germ Cell Neoplasm

Germ Cell Tumour

Malignant Tumor Of The Germ Cell

Neoplasms Germ Cell

Malignant Germ Cell Neoplasm

Rickets

Vitamin D Deficiency

Vitamin D

Active Rickets

Hypovitaminosis D

Nutritional Rickets

Vitamin D Deficiency Disease

Vitamin-D Deficiency Rickets

Vitamin D-Dependent Rickets

Avitaminosis D

Infantile Osteomalacia

Juvenile Osteomalacia

Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis

Alkaline Phosphatase, Plasma Level Of, Quantitative Trait Locus 1

Alkaline Phosphatase, Elevated Serum

Alpqtl1

Hyperphosphatasemia, Benign Familial

Hypophosphatasia, Infantile

Infantile Hypophosphatasia

HPPI

Hops

Phosphoethanolaminuria

Perinatal Lethal Hypophosphatasia

Perinatal Lethal Rathbun Disease

Perinatal Lethal Phosphoethanolaminuria

Infantile Rathbun Disease

Infantile Phosphoethanolaminuria

Hypophosphatasia, Perinatal Lethal

Osteomalacia

Adult Rickets

Bone Disease

Bone Diseases

Skeletal Disease

Skeletal Disorder

Disorder Of Skeletal System

Endodermal Sinus Tumor

Yolk Sac Tumor

Endodermal Sinus Tumour

Hepatoid Yolk Sac Tumour

Infantile Embryonal Carcinoma

Yolk Sac Neoplasm

Yolk Sac Tumour

Fascioliasis

Fasciola Hepatica Infection

Infection By Fasciola

Sheep Liver Fluke Infection

Liver Flukes

Fasciola Infestation

Sheep Liver Fluke Disease

Liver Fluke Infestation

Liver Flukes Nos

Liver Fluke Infection

Liver Fluke Disease

Waardenburg Syndrome, Type 1

Waardenburg Syndrome Type 1

WS1

Waardenburg Syndrome Type I

Waardenburg Syndrome With Dystopia Canthorum

Waardenburg'S Syndrome Type 1

Waardenburg Syndrome 1

Waardenburg Syndrome, Type I

Waardenburg Syndrome

Serous Cystadenocarcinoma

Serous Adenocarcinoma

Cystadenocarcinoma, Serous

Serous Carcinoma

Cystadenocarcinoma Serous

Diamond-Blackfan Anemia 13

DBA13

Rps29-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 13

Choriocarcinoma

Chorioepithelioma

Primary Hyperparathyroidism

Familial Primary Hyperparathyroidism

Hyperparathyroidism, Primary

Hyperparathyroidism Primary

Hypocalciuric Hypercalcemia, Familial, Type 1

Familial Benign Hypercalcemia

Familial Hyperparathyroidism

Parathyroid Enlargement

Dysgerminoma
Hypoparathyroidism

Hypoparathyroidism, Idiopathic

Parathyroid, Underactivity Of

Syndrome With Hypoparathyroidism

Deficiency Of Parathyroid Hormone

Parathyroid Gland Insufficiency

Parathyroid Insufficiency

Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion

Gonadoblastoma

GBY

Periostitis
Cholangitis

Acute Cholangiolitis

Ascending Cholangitis

Cholangiolitis

Cholangitis Nos

Chronic Cholangiolitis

Hepatic Duct Inflammation

Acute Cholangitis

Bile Duct Inflammation

Hyperparathyroidism

Hyperparathyroidism And Other Disorders Of Parathyroid Gland

Parathyroid Hyperfunction

Hpth - [Hyperparathyroidism]

Parathyroid Gland Hyperfunction

Parathyroid Glandular Hyperfunction

Liver Disease

Liver Failure

Liver Diseases

Abnormality Of The Liver

Liver Dysfunction

Disorder Of Liver

Hepatic Disorder

Hepatic Disease

Disease Of Bilirubin Metabolism

Disorder Of Bilirubin Metabolism

Liver Decompensation

Liver Function Failure

Hepatic Failure Nos

Liver Failure Nos

End Stage Liver Disease

Decompensated Liver Failure

Decompensation Of Liver Function

Hepatic Decompensation

Hepatic Insufficiency

Liver Cell Necrosis With Hepatic Failure

Liver Insufficiency

Decompensated Liver Disease

End Stage Liver Failure

Liver Necrosis With Hepatic Failure

Cholestasis

Obstruction Of Bile Duct

Bile Duct Obstruction

Bile Occlusion

Extrahepatic Biliary Obstruction

Extrahepatic Bile Duct Obstruction

Bile Stasis

Biliary Stasis

Obstructive Hyperbilirubinemia

Obstructed Jaundice

Bile Duct Obstructed

Bile Ductal Obstruction

Biliary Duct Obstruction

Obstructed Bile Ductal

Obstructed Biliary Duct

Obstructed Biliary Ductal

Jaundice Regurgitation

Obstructive Jaundice

Cholestatic Jaundice

Cholestatic Jaundice Syndrome

Female Stress Incontinence

Female Urinary Stress Incontinence

Stress Incontinence - Female

Choledocholithiasis
Parathyroid Adenoma

Adenoma Of Parathyroid

Adenoma Of The Parathyroid Gland

Parathyroid Gland Adenoma

Intrahepatic Cholestasis

Cholestasis, Intrahepatic

Neonatal Intrahepatic Cholestasis

Cholestasis Intrahepatic

Cholestasis Of Pregnancy

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Cystadenocarcinoma
Waardenburg'S Syndrome

Waardenburg Syndrome

Van Der Hoeve Halbertsma Waardenburg Gualdi Syndrome

Van Der Hoeve Halbertsona Waardenburg Syndrome

Waardenburg Shah Syndrome

Waardenburg, Types I And/Or Ii

Mende Syndrome

Waardenburgs Syndrome

Waardenburg Syndrome, Type 4a

Sertoli-Leydig Cell Tumor

Sertoli-Leydig Cell Tumors

Androblastoma Of Ovary

Arrhenoblastoma

Arrhenoblastoma Of Ovary

Sertoli-Leydig Cell Tumor Of The Ovary

Sertoli-Leydig Cell Tumor Of Intermediate Differentiation

Sertoli-Leydig Cell Tumor Of Ovary

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Low Compliance Bladder

Overactive Bladder

Hyperactivity Of Bladder

Hypertonic Bladder

Hypertonicity Of Bladder

Low Bladder Compliance

Oab - [Overactive Bladder]

Cleidocranial Dysplasia

Cleidocranial Dysostosis

CLCD

Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only

Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly

CCD

Marie-Sainton Disease

Dysplasia Cleidocranial

Dento-Osseous Dysplasia

Marie-Sainton Syndrome

Dysplasia, Cleidocranial

Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ALPP MGD MGI:1924018
Rattus norvegicus ALPP RGD RGD:2325055
Macaca fascicularis ALPP NCBI
Others ALPP NCBI