2. Gene
  3. Hsd11b1 - hydroxysteroid 11-beta dehydrogenase 1 Gene

Hsd11b1 - hydroxysteroid 11-beta dehydrogenase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: LRRGT00065

基因 ID: 25116 | 基因类型: protein coding

关于 Hsd11b1

功能概要

Enables NADP binding activity and steroid binding activity. Involved in several processes, including cellular response to estradiol stimulus; glucocorticoid metabolic process; and regulation of pentose-phosphate shunt. Located in apical part of cell; nuclear membrane; and rough endoplasmic reticulum. Used to study obesity. Biomarker of familial hyperlipidemia; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in cortisone reductase deficiency and cortisone reductase deficiency 2. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsd11b1 基因产物(1)

mRNA Protein Name
NM_017080.2 NP_058776.2 11-beta-hydroxysteroid dehydrogenase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NADP binding IDA
IDA: 通过直接分析推断
15761036 RGD
enables steroid binding IPI
IPI: 通过物理相互作用推断
15761036 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
19380458 RGD
involved in glucocorticoid biosynthetic process IDA
IDA: 通过直接分析推断
12460758 RGD
involved in glucocorticoid catabolic process IDA
IDA: 通过直接分析推断
12460758 RGD
involved in mineralocorticoid metabolic process IDA
IDA: 通过直接分析推断
2808402 RGD
involved in regulation of pentose-phosphate shunt IDA
IDA: 通过直接分析推断
16234247 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
16941667 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
12810566 RGD
located in nuclear membrane IDA
IDA: 通过直接分析推断
11250946 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

11-beta-hydroxysteroid dehydrogenase 1

corticosteroid 11-beta-dehydrogenase isozyme 1

11-DH

11-beta-HSD1

11-beta-hydroxysteroid dehydrogenase, type 1

11beta-HSD1

7-oxosteroid reductase

cortocosteroid 11-beta dehydrogenase

hydroxysteroid dehydrogenase, 11 beta type 1

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06387 HSD11B1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-167696 11β-HSD1-IN-16 Inhibitor / 否
HY-RS20631 Hsd11b1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27140 Hsd11b1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hsd11b1 NCBI NCBI:3290
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