2. Gene
  3. CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞色素 P450 ，家族 19 ，亚家族 a，多肽 1

种属: Rattus norvegicus

同用名: Cyp19; Cyp19a; p450arom; Aromatase

基因 ID: 25147 | 基因类型: protein coding

关于 CYP19A1

Primary_assembly 8: 54,553,165-54,580,758 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 319 orthologues, 17 paralogues and is associated with 48 phenotypes. Biased expression in Brain (RPKM 2.6), Uterus (RPKM 2.1) and 7 other tissues.

功能概要

该基因编码的蛋白可启动芳香酶活性。参与多个过程，包括动物器官发育；羧酸代谢过程；和细胞激素代谢过程。位于多个细胞成分中，包括树突棘；神经细胞体；和突触小泡。用于研究子宫内膜异位症和多囊卵巢综合征。高血压的生物标志物；甲状腺功能减退症;胎盘功能不全;多囊卵巢综合征;和蛋白质能量营养不良。该基因的人类直系同源物与多种疾病有关，包括芳香化酶过多综合征；膀胱颈梗阻；食道腺癌；卵巢疾病（多发性）；和前列腺疾病（多种）。与人类 CYP19A1（细胞色素 P450 家族 19 亚家族 A 成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables aromatase activity. Involved in several processes, including animal organ development; carboxylic acid metabolic process; and cellular hormone metabolic process. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (Cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

CYP19A1 基因产物(1)

mRNA Protein Name
NM_017085.3 NP_058781.2 aromatase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aromatase activity IDA
IDA: 通过直接分析推断
16269516 RGD
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
IDA: 通过直接分析推断
11850226 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in C21-steroid hormone metabolic process IDA
IDA: 通过直接分析推断
19190754 RGD
involved in adrenal gland development IEP
IEP: 通过表达模式推断
8097866 RGD
involved in androgen metabolic process IMP
IMP: 通过突变表型推断
19492405 RGD
involved in bile acid metabolic process IEP
IEP: 通过表达模式推断
20026603 RGD
involved in biphenyl metabolic process IEP
IEP: 通过表达模式推断
19464308 RGD
involved in bone development IEP
IEP: 通过表达模式推断
15012600 RGD
involved in calcineurin-mediated signaling IMP
IMP: 通过突变表型推断
25057110 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: 通过表达模式推断
20434519 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
20810564 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
18353182 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: 通过表达模式推断
16569475 RGD
involved in cellular response to hydrostatic pressure IEP
IEP: 通过表达模式推断
21047944 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: 通过表达模式推断
20059580 RGD
involved in estrogen biosynthetic process IDA
IDA: 通过直接分析推断
19665544 RGD
involved in granulocyte differentiation IEP
IEP: 通过表达模式推断
18401763 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
21047951 RGD
involved in hypothalamus development IEP
IEP: 通过表达模式推断
15804399 RGD
involved in luteinization IEP
IEP: 通过表达模式推断
23183184 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
20554652 RGD
involved in melatonin metabolic process IEP
IEP: 通过表达模式推断
17700567 RGD
involved in negative regulation of bone resorption IMP
IMP: 通过突变表型推断
8694895 RGD
involved in phthalate metabolic process IEP
IEP: 通过表达模式推断
20920559 RGD
involved in regulation of synapse structure or activity IMP
IMP: 通过突变表型推断
17005180 RGD
involved in response to cesium ion IEP
IEP: 通过表达模式推断
20451883 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
21115103 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
19734697 RGD
involved in response to herbicide IEP
IEP: 通过表达模式推断
21126571 RGD
involved in response to ionizing radiation IEP
IEP: 通过表达模式推断
18821396 RGD
involved in response to metal ion IEP
IEP: 通过表达模式推断
20708649 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
20821433 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
16569475 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19497980 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon terminus IDA
IDA: 通过直接分析推断
14694190 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
14694190 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
19565659 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
14694190 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
20926671 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CYP19A1 蛋白结构

CYP19A1

CYP19A1: cd20616 (71 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
蛋白主名 其他名称

aromatase

CYPXIX

Cytochrome P450, 19, aromatase

P-450AROM

cytochrome P-450AROM

cytochrome P450 19A1

cytochrome P450 19A1-like

cytochrome P450 family 19 subfamily a

cytochrome P450, subfamily 19

estrogen synthase

estrogen synthetase

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150775 CYP19A1-IN-2 Inhibitor 98.88% 否
HY-155493 CYP19A1/CYP11B2-IN-1 Inhibitor 99.85% 否
HY-173279 CYP19A1-IN-1 Inhibitor / 否
HY-RS03438 CYP19A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03439 Cyp19a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS03440 CYP19A1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-Z4488 5-Dibromomethyl anastrozole Control / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens CYP19A1 NCBI NCBI:1588
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