1. Gene
  2. CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

中文名称:细胞色素 P450 ,家族 19 ,亚家族 a,多肽 1

种属: Rattus norvegicus

同用名: Cyp19; Cyp19a; p450arom; Aromatase

基因 ID: 25147 | 基因类型: protein coding

关于 CYP19A1

Primary_assembly 8: 54,553,165-54,580,758 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 319 orthologues, 17 paralogues and is associated with 48 phenotypes. Biased expression in Brain (RPKM 2.6), Uterus (RPKM 2.1) and 7 other tissues.

功能概要

该基因编码的蛋白可启动芳香酶活性。参与多个过程,包括动物器官发育;羧酸代谢过程;和细胞激素代谢过程。位于多个细胞成分中,包括树突棘;神经细胞体;和突触小泡。用于研究子宫内膜异位症和多囊卵巢综合征。高血压的生物标志物;甲状腺功能减退症;胎盘功能不全;多囊卵巢综合征;和蛋白质能量营养不良。该基因的人类直系同源物与多种疾病有关,包括芳香化酶过多综合征;膀胱颈梗阻;食道腺癌;卵巢疾病(多发性);和前列腺疾病(多种)。与人类 CYP19A1(细胞色素 P450 家族 19 亚家族 A 成员 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables aromatase activity. Involved in several processes, including animal organ development; carboxylic acid metabolic process; and cellular hormone metabolic process. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (Cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

CYP19A1 基因产物(1)

mRNA Protein Name
NM_017085.3 NP_058781.2 aromatase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in C21-steroid hormone metabolic process IDA
IDA: 通过直接分析推断
19190754 RGD
involved in adrenal gland development IEP
IEP: 通过表达模式推断
8097866 RGD
involved in androgen metabolic process IMP
IMP: 通过突变表型推断
19492405 RGD
involved in bile acid metabolic process IEP
IEP: 通过表达模式推断
20026603 RGD
involved in biphenyl metabolic process IEP
IEP: 通过表达模式推断
19464308 RGD
involved in bone development IEP
IEP: 通过表达模式推断
15012600 RGD
involved in calcineurin-mediated signaling IMP
IMP: 通过突变表型推断
25057110 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: 通过表达模式推断
20434519 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
20810564 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
18353182 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: 通过表达模式推断
16569475 RGD
involved in cellular response to hydrostatic pressure IEP
IEP: 通过表达模式推断
21047944 RGD
involved in dibenzo-p-dioxin metabolic process IEP
IEP: 通过表达模式推断
20059580 RGD
involved in estrogen biosynthetic process IDA
IDA: 通过直接分析推断
19665544 RGD
involved in granulocyte differentiation IEP
IEP: 通过表达模式推断
18401763 RGD
involved in hippocampus development IEP
IEP: 通过表达模式推断
21047951 RGD
involved in hypothalamus development IEP
IEP: 通过表达模式推断
15804399 RGD
involved in luteinization IEP
IEP: 通过表达模式推断
23183184 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
20554652 RGD
involved in melatonin metabolic process IEP
IEP: 通过表达模式推断
17700567 RGD
involved in negative regulation of bone resorption IMP
IMP: 通过突变表型推断
8694895 RGD
involved in phthalate metabolic process IEP
IEP: 通过表达模式推断
20920559 RGD
involved in regulation of synapse structure or activity IMP
IMP: 通过突变表型推断
17005180 RGD
involved in response to cesium ion IEP
IEP: 通过表达模式推断
20451883 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
21115103 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
19734697 RGD
involved in response to herbicide IEP
IEP: 通过表达模式推断
21126571 RGD
involved in response to ionizing radiation IEP
IEP: 通过表达模式推断
18821396 RGD
involved in response to metal ion IEP
IEP: 通过表达模式推断
20708649 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
20821433 RGD
involved in response to testosterone IEP
IEP: 通过表达模式推断
16569475 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19497980 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon terminus IDA
IDA: 通过直接分析推断
14694190 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
14694190 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
19565659 RGD
located in synaptic vesicle IDA
IDA: 通过直接分析推断
14694190 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
20926671 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CYP19A1 蛋白结构

CYP19A1

CYP19A1: cd20616 (71 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
蛋白主名 其他名称

aromatase

CYPXIX

Cytochrome P450, 19, aromatase

P-450AROM

cytochrome P-450AROM

cytochrome P450 19A1

cytochrome P450 19A1-like

cytochrome P450 family 19 subfamily a

cytochrome P450, subfamily 19

estrogen synthase

estrogen synthetase

直系同源

种属 基因名 来源 基因 ID
Homo sapiens CYP19A1 NCBI NCBI:1588