2. Gene
  3. Igf2r - insulin-like growth factor 2 receptor Gene

Igf2r - insulin-like growth factor 2 receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Igfr2; IGF-IIR

基因 ID: 25151 | 基因类型: protein coding

关于 Igf2r

功能概要

Enables several functions, including G-protein alpha-subunit binding activity; insulin-like growth factor II binding activity; and retinoic acid binding activity. Involved in several processes, including animal organ regeneration; response to retinoic acid; and response to tetrachloromethane. Located in several cellular components, including extracellular space; late endosome; and perinuclear region of cytoplasm. Part of clathrin coat. Colocalizes with trans-Golgi network. Used to study lung adenocarcinoma. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (Insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf2r 基因产物(1)

mRNA Protein Name
NM_012756.2 NP_036888.2 cation-independent mannose-6-phosphate receptor precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G-protein alpha-subunit binding IDA
IDA: 通过直接分析推断
16407557 RGD
enables enzyme binding IDA
IDA: 通过直接分析推断
11247783 RGD
enables insulin-like growth factor II binding IDA
IDA: 通过直接分析推断
16407557 RGD
enables retinoic acid binding IDA
IDA: 通过直接分析推断
10470859 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
19095737 RGD
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
12547403 RGD
involved in liver development IDA
IDA: 通过直接分析推断
12127995 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
19095737 RGD
involved in post-embryonic development IEP
IEP: 通过表达模式推断
18824840 RGD
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
16825605 RGD
involved in response to retinoic acid IDA
IDA: 通过直接分析推断
9811861 RGD
involved in response to tetrachloromethane IEP
IEP: 通过表达模式推断
9632637 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
10993842 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of clathrin coat IDA
IDA: 通过直接分析推断
2971973 RGD
located in endosome IDA
IDA: 通过直接分析推断
15033478 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
10470859 RGD
located in late endosome IDA
IDA: 通过直接分析推断
19337031 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15033478 RGD
located in trans-Golgi network IDA
IDA: 通过直接分析推断
15033478 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cation-independent mannose-6-phosphate receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06622 IGF2R Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17981 Igf2r Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24452 Igf2r Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Igf2r NCBI NCBI:3482
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