2. Gene
  3. Cdkn2a - cyclin-dependent kinase inhibitor 2A Gene

Cdkn2a - cyclin-dependent kinase inhibitor 2A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Arf; p16; MTS1; INK4A; p19ARF; p16Cdkn2a

基因 ID: 25163 | 基因类型: protein coding

关于 Cdkn2a

功能概要

Predicted to enable several functions, including MDM2/MDM4 family protein binding activity; NF-kappaB binding activity; and enzyme inhibitor activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of hepatocyte proliferation; and nervous system development. Located in cytoplasm and nucleus. Used to study carcinoma (multiple); endometrial cancer; pre-malignant neoplasm; rhabdomyosarcoma; and sarcomatoid mesothelioma. Biomarker of hepatocellular carcinoma; hypertension; obesity; and osteoarthritis. Human ortholog(s) of this gene implicated in several diseases, including breast Cancer (multiple); hematologic Cancer (multiple); melanoma (multiple); nervous system Cancer (multiple); and pancreatic Cancer (multiple). Orthologous to human CDKN2A (cyclin dependent kinase inhibitor 2A). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn2a 基因产物(1)

mRNA Protein Name
NM_031550.2 NP_113738.1 cyclin-dependent kinase inhibitor 2A
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
20943765 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
9693786 RGD
involved in negative regulation of hepatocyte proliferation IMP
IMP: 通过突变表型推断
24190239 RGD
involved in neurogenesis IEP
IEP: 通过表达模式推断
19114593 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
22020338 RGD
involved in response to caloric restriction IEP
IEP: 通过表达模式推断
15520862 RGD
involved in response to fatty acid IEP
IEP: 通过表达模式推断
22395468 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
18204080 RGD
involved in response to salt stress IEP
IEP: 通过表达模式推断
19826180 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
17706854 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
12189186 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cyclin-dependent kinase inhibitor 2A

CDK4I

Cyclin dependent kinase inhibitor 2A (p16, inhibits CDK4)

alternative reading frame

cell cycle inhibitor

cell cycle regulator

cyclin-dependent kinase 4 inhibitor A

cyclin-dependent kinase inhibitor 2a p16Ink4a

cyclin-dependent kinase inhibito

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119344 MS37452 Inhibitor 99.81% 否
HY-138684 MRTX9768 Inhibitor 99.60% 否
HY-138684A MRTX9768 hydrochloride Inhibitor 99.88% 否
HY-RS02414 CDKN2A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16723 Cdkn2a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23159 Cdkn2a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdkn2a NCBI NCBI:1029
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