2. Gene
  3. P2ry1 - purinergic receptor P2Y1 Gene

P2ry1 - purinergic receptor P2Y1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2Y1

种属: Rattus norvegicus

同用名: P2y; P2y1

基因 ID: 25265 | 基因类型: protein coding

关于 P2ry1

Primary_assembly 2: 145,241,849-145,248,457 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 191 orthologues, 13 paralogues and is associated with 3 phenotypes. Biased expression in Muscle (RPKM 119.4), Spleen (RPKM 41.7) and 8 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 A1 腺苷受体结合活性； G 蛋白偶联嘌呤核苷酸受体活性；和腺苷酸核糖核苷酸结合活性。涉及多个过程，包括嘌呤能核苷酸受体信号通路；细胞溶质钙离子浓度的调节；和细胞分泌的调节。位于几种细胞成分中，包括顶端质膜；基底外侧质膜；和突触后密度。在谷氨酸能突触中活跃。是突触前活动区膜的组成部分。与线粒体共定位。用于研究阳痿。与人 P2RY1（嘌呤能受体 P2Y1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including A1 Adenosine Receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Involved in several processes, including purinergic nucleotide receptor signaling pathway; regulation of cytosolic calcium ion concentration; and regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with mitochondrion. Used to study impotence. Orthologous to human P2RY1 (purinergic receptor P2Y1). [provided by Alliance of Genome Resources, Apr 2022]

P2ry1 基因产物(1)

mRNA Protein Name
NM_012800.3 NP_036932.1 P2Y purinoceptor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables A1 adenosine receptor binding IPI
IPI: 通过物理相互作用推断
11390975 RGD
enables ADP binding IDA
IDA: 通过直接分析推断
15152027 RGD
enables ATP binding IDA
IDA: 通过直接分析推断
11557527 RGD
enables G protein-coupled ADP receptor activity IDA
IDA: 通过直接分析推断
20847060 RGD
enables G protein-coupled ATP receptor activity IDA
IDA: 通过直接分析推断
20847060 RGD
enables G protein-coupled purinergic nucleotide receptor activity IDA
IDA: 通过直接分析推断
15152027 RGD
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
11390975 RGD
enables scaffold protein binding IPI
IPI: 通过物理相互作用推断
20847060 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled adenosine receptor signaling pathway IDA
IDA: 通过直接分析推断
20847060 RGD
involved in G protein-coupled purinergic nucleotide receptor signaling pathway IDA
IDA: 通过直接分析推断
20847060 RGD
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15152027 RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11390975 RGD
involved in blood vessel diameter maintenance IMP
IMP: 通过突变表型推断
12730558 RGD
involved in eating behavior IMP
IMP: 通过突变表型推断
17067301 RGD
involved in glial cell migration IMP
IMP: 通过突变表型推断
20681951 RGD
NOT involved in microglial cell activation IMP
IMP: 通过突变表型推断
11245682 RGD
involved in negative regulation of norepinephrine secretion IDA
IDA: 通过直接分析推断
19447154 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
20847060 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
20847060 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
19373936 RGD
involved in positive regulation of hormone secretion IDA
IDA: 通过直接分析推断
19515986 RGD
involved in positive regulation of inositol trisphosphate biosynthetic process IDA
IDA: 通过直接分析推断
11390975 RGD
involved in positive regulation of penile erection IDA
IDA: 通过直接分析推断
19303093 RGD
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
20847060 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
20847060 RGD
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
20847060 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IEP
IEP: 通过表达模式推断
16000618 RGD
involved in regulation of signaling receptor activity IDA
IDA: 通过直接分析推断
11390975 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IEP
IEP: 通过表达模式推断
16000618 RGD
involved in response to growth factor IEP
IEP: 通过表达模式推断
14714568 RGD
involved in response to mechanical stimulus IMP
IMP: 通过突变表型推断
14689471 RGD
involved in signal transduction involved in regulation of gene expression IDA
IDA: 通过直接分析推断
20847060 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
11557527 RGD
located in cell body IDA
IDA: 通过直接分析推断
12417330 RGD
located in dendrite IDA
IDA: 通过直接分析推断
12417330 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16000618 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
16000618 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
20847060 RGD
located in postsynaptic density IDA
IDA: 通过直接分析推断
20847060 RGD
located in postsynaptic membrane IDA
IDA: 通过直接分析推断
20847060 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
16000618 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2ry1 蛋白结构

7tmA_P2Y1

7tmA_P2Y1: cd15377 (51 - 334)

7tmA_P2Y1

7tmA_P2Y1: cd15377 (51 - 78)

7tmA_P2Y1

7tmA_P2Y1: cd15377 (85 - 110)

7tmA_P2Y1

7tmA_P2Y1: cd15377 (123 - 153)

7tmA_P2Y1

7tmA_P2Y1: cd15377 (165 - 187)

7tmA_P2Y1

7tmA_P2Y1: cd15377 (213 - 242)

7tmA_P2Y1

7tmA_P2Y1: cd15377 (252 - 282)

7tmA_P2Y1

7tmA_P2Y1: cd15377 (302 - 327)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

P2Y purinoceptor 1

ATP receptor

P2 purinoreceptor subclass 2Y

P2Y ATP receptor 1

purinergic receptor P2Y, G-protein coupled, 1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09914 P2RY1 Human Pre-designed siRNA Set A / 否
HY-RS09915 P2ry1 Mouse Pre-designed siRNA Set A / 否
HY-RS09916 P2ry1 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2ry1 NCBI NCBI:5028
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