2. Gene
  3. Gclc - glutamate-cysteine ligase, catalytic subunit Gene

Gclc - glutamate-cysteine ligase, catalytic subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Glclc

基因 ID: 25283 | 基因类型: protein coding

关于 Gclc

功能概要

Enables glutamate-cysteine Ligase activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Part of glutamate-cysteine Ligase complex. Used to study liver cirrhosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in cystic fibrosis; glutamate-cysteine Ligase deficiency; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine Ligase catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Gclc 基因产物(1)

mRNA Protein Name
NM_012815.2 NP_036947.1 glutamate--cysteine ligase catalytic subunit
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables glutamate-cysteine ligase activity IDA
IDA: 通过直接分析推断
12425961 RGD
enables glutamate-cysteine ligase activity IMP
IMP: 通过突变表型推断
16183645 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
16137247 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: 通过表达模式推断
18042181 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
18042181 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
20466058 RGD
involved in cellular response to hepatocyte growth factor stimulus IEP
IEP: 通过表达模式推断
20466058 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
15169830 RGD
involved in cellular response to mechanical stimulus IEP
IEP: 通过表达模式推断
20054150 RGD
involved in cellular response to thyroxine stimulus IEP
IEP: 通过表达模式推断
17291985 RGD
involved in glutathione biosynthetic process IMP
IMP: 通过突变表型推断
16183645 RGD
involved in negative regulation of hepatic stellate cell activation IMP
IMP: 通过突变表型推断
22942279 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
16183645 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
20018823 RGD
involved in response to cadmium ion IEP
IEP: 通过表达模式推断
10702364 RGD
involved in response to human chorionic gonadotropin IEP
IEP: 通过表达模式推断
15811874 RGD
involved in response to interleukin-1 IEP
IEP: 通过表达模式推断
15485876 RGD
involved in response to nitrosative stress IMP
IMP: 通过突变表型推断
16183645 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
22906634 RGD
involved in response to oxidative stress IMP
IMP: 通过突变表型推断
16183645 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of glutamate-cysteine ligase complex IDA
IDA: 通过直接分析推断
16137247 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

glutamate--cysteine ligase catalytic subunit

GCS heavy chain

Glutamylcysteine gamma synthetase light chain

gamma-ECS

gamma-glutamylcysteine synthetase

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W015600 2-Acetamidophenol 99.61% 否
HY-RS05333 GCLC Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-147517 Keap1-Nrf2-IN-9 Inhibitor 98.52% 否
HY-RS17688 Gclc Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24150 Gclc Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gclc NCBI NCBI:2729
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