2. Gene
  3. Chrna7 - cholinergic receptor nicotinic alpha 7 subunit Gene

Chrna7 - cholinergic receptor nicotinic alpha 7 subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: BTX; NARAD; nAChRa7

基因 ID: 25302 | 基因类型: protein coding

关于 Chrna7

功能概要

Enables several functions, including acetylcholine binding activity; acetylcholine-gated cation-selective channel activity; and enzyme binding activity. Involved in several processes, including dopamine biosynthetic process; neuronal action potential; and regulation of ERK1 and ERK2 cascade. Acts upstream of or within calcium ion transport and regulation of membrane potential. Located in several cellular components, including dendrite; plasma membrane raft; and postsynaptic density. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse and glycinergic synapse. Is integral component of postsynaptic specialization membrane; integral component of presynaptic membrane; and integral component of spine apparatus membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including CHRFAM7A (CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion). [provided by Alliance of Genome Resources, Apr 2022]

Chrna7 基因产物(1)

mRNA Protein Name
NM_012832.4 NP_036964.3 neuronal acetylcholine receptor subunit alpha-7 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATPase binding IDA
IDA: 通过直接分析推断
22593058 RGD
enables acetylcholine binding IDA
IDA: 通过直接分析推断
11297818 RGD
enables acetylcholine binding IMP
IMP: 通过突变表型推断
16186249 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IDA
IDA: 通过直接分析推断
11222635 RGD
enables acetylcholine-gated monoatomic cation-selective channel activity IMP
IMP: 通过突变表型推断
11259617 RGD
enables adenylate cyclase binding IPI
IPI: 通过物理相互作用推断
12748066 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10627589 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
12244045 RGD
enables scaffold protein binding IDA
IDA: 通过直接分析推断
22593058 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential EXP
EXP: 通过实验结果推断
15044058 RGD
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: 通过直接分析推断
15044058 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetylcholine receptor signaling pathway IDA
IDA: 通过直接分析推断
21540349 RGD
acts upstream of or within calcium ion transport IMP
IMP: 通过突变表型推断
15760934 RGD
involved in dopamine biosynthetic process IEP
IEP: 通过表达模式推断
12438507 RGD
involved in learning or memory IMP
IMP: 通过突变表型推断
17055644 RGD
involved in memory IDA
IDA: 通过直接分析推断
17898229 RGD
involved in monoatomic ion transmembrane transport IDA
IDA: 通过直接分析推断
16282518 RGD
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
20505147 RGD
involved in neuronal action potential IMP
IMP: 通过突变表型推断
15044058 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
17898229 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
11404397 RGD
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
17379406 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
21762741 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
21762741 RGD
acts upstream of or within regulation of membrane potential IDA
IDA: 通过直接分析推断
11222635 RGD
acts upstream of or within regulation of membrane potential IMP
IMP: 通过突变表型推断
15760934 RGD
involved in regulation of response to drug IDA
IDA: 通过直接分析推断
16282518 RGD
involved in response to acetylcholine IDA
IDA: 通过直接分析推断
16282518 RGD
involved in response to carbamate IEP
IEP: 通过表达模式推断
15179037 RGD
involved in response to nicotine IDA
IDA: 通过直接分析推断
15801858 RGD
involved in response to nicotine IGI
IGI: 通过遗传相互作用推断
11404397 RGD
involved in sensory processing IDA
IDA: 通过直接分析推断
17898229 RGD
involved in synaptic transmission, cholinergic IMP
IMP: 通过突变表型推断
15044058 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of acetylcholine-gated channel complex IDA
IDA: 通过直接分析推断
11259617 RGD
located in asymmetric synapse IDA
IDA: 通过直接分析推断
12077196 RGD
located in axon IDA
IDA: 通过直接分析推断
12077196 RGD
is active in cholinergic synapse EXP
EXP: 通过实验结果推断
15044058 RGD
is active in cholinergic synapse IDA
IDA: 通过直接分析推断
15044058 RGD
located in dendrite IDA
IDA: 通过直接分析推断
11297818 RGD
located in dendritic shaft IDA
IDA: 通过直接分析推断
12077196 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
12077196 RGD
is active in glycinergic synapse EXP
EXP: 通过实验结果推断
21762741 RGD
is active in glycinergic synapse IDA
IDA: 通过直接分析推断
21762741 RGD
located in growth cone IDA
IDA: 通过直接分析推断
12645078 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
11297818 RGD
located in plasma membrane raft IDA
IDA: 通过直接分析推断
21540349 RGD
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
24607281 RGD
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
11588172 RGD
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
11588172 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
12077196 RGD
is active in spine apparatus membrane IDA
IDA: 通过直接分析推断
11588172 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neuronal acetylcholine receptor subunit alpha-7

C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)

bungarotoxin alpha

cholinergic receptor, nicotinic, alpha 7 (neuronal)

cholinergic receptor, nicotinic, alpha polypeptide 7

n

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02672 CHRNA7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS02659 CHRFAM7A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19768 Chrna7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26265 Chrna7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Chrna7 NCBI NCBI:1139
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z