2. Gene
  3. Oxtr - oxytocin receptor Gene

Oxtr - oxytocin receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：催产素受体

种属: Rattus norvegicus

同用名: OTR; OT-R; OTR1

基因 ID: 25342 | 基因类型: protein coding

关于 Oxtr

Primary_assembly 4: 145,599,561-145,614,674 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 265 orthologues, 16 paralogues and is associated with 25 phenotypes. Biased expression in Adrenal (RPKM 17.2), Uterus (RPKM 11.7) and 7 other tissues.

功能概要

该基因编码的蛋白可启动催产素受体活性和肽激素结合活性。涉及多个过程，包括ERK1和ERK2级联；突触传递的正向调节；和分泌调节。位于adherens路口；顶端质膜；和微绒毛。用于研究胃溃疡。高血压的生物标志物。与人类 OXTR（催产素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Oxytocin Receptor activity and peptide hormone binding activity. Involved in several processes, including ERK1 and ERK2 cascade; positive regulation of synaptic transmission; and regulation of secretion. Located in adherens junction; apical plasma membrane; and microvillus. Used to study gastric ulcer. Biomarker of hypertension. Orthologous to human OXTR (Oxytocin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Oxtr 基因产物(1)

mRNA Protein Name
NM_012871.4 NP_037003.2 oxytocin receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ionotropic glutamate receptor binding IPI
IPI: 通过物理相互作用推断
25539504 RGD
enables oxytocin receptor activity IDA
IDA: 通过直接分析推断
15821089 RGD
enables peptide hormone binding IDA
IDA: 通过直接分析推断
15821089 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9176188 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
10497238 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9575824 RGD
involved in digestive tract development IEP
IEP: 通过表达模式推断
19003903 RGD
involved in eating behavior IMP
IMP: 通过突变表型推断
15380376 RGD
involved in estrous cycle IEP
IEP: 通过表达模式推断
12867731 RGD
involved in female pregnancy IEP
IEP: 通过表达模式推断
16832906 RGD
involved in heart development IEP
IEP: 通过表达模式推断
15316117 RGD
involved in maternal behavior IMP
IMP: 通过突变表型推断
18513132 RGD
involved in maternal process involved in parturition IEP
IEP: 通过表达模式推断
18936075 RGD
involved in memory IMP
IMP: 通过突变表型推断
18304743 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
10497238 RGD
involved in positive regulation of norepinephrine secretion IMP
IMP: 通过突变表型推断
14656297 RGD
involved in positive regulation of penile erection IMP
IMP: 通过突变表型推断
18469843 RGD
involved in positive regulation of synapse assembly IMP
IMP: 通过突变表型推断
16488155 RGD
involved in positive regulation of synaptic transmission, GABAergic IMP
IMP: 通过突变表型推断
11069593 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: 通过突变表型推断
18510735 RGD
involved in positive regulation of uterine smooth muscle contraction IMP
IMP: 通过突变表型推断
19164477 RGD
involved in response to amphetamine IMP
IMP: 通过突变表型推断
17383105 RGD
involved in response to anoxia IMP
IMP: 通过突变表型推断
18655887 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
16677710 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
10994633 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
19258489 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
11264328 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
12700188 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
10856882 RGD
involved in response to steroid hormone IMP
IMP: 通过突变表型推断
12588901 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
12834913 RGD
involved in social behavior IMP
IMP: 通过突变表型推断
17383105 RGD
involved in sperm ejaculation IMP
IMP: 通过突变表型推断
18469843 RGD
involved in suckling behavior IMP
IMP: 通过突变表型推断
19106214 RGD
involved in telencephalon development IEP
IEP: 通过表达模式推断
11021977 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
19003903 RGD
located in apical plasma membrane IDA
IDA: 通过直接分析推断
11456414 RGD
located in microvillus IDA
IDA: 通过直接分析推断
11456414 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Oxtr 蛋白结构

7tmA_OT_R

7tmA_OT_R: cd15387 (39 - 338)

7tmA_OT_R

7tmA_OT_R: cd15387 (40 - 66)

7tmA_OT_R

7tmA_OT_R: cd15387 (73 - 100)

7tmA_OT_R

7tmA_OT_R: cd15387 (111 - 141)

7tmA_OT_R

7tmA_OT_R: cd15387 (151 - 172)

7tmA_OT_R

7tmA_OT_R: cd15387 (196 - 225)

7tmA_OT_R

7tmA_OT_R: cd15387 (266 - 296)

7tmA_OT_R

7tmA_OT_R: cd15387 (306 - 331)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

oxytocin receptor

oxcytocin receptor

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108678 TC OT 39 97.70% 否
HY-P4990A Pro8-Oxytocin TFA Activator 99.68% 否
HY-P4990 Pro8-Oxytocin Activator / 否
HY-P5017 (Val3,Pro8)-Oxytocin Agonist / 否
HY-RS09894 OXTR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09895 Oxtr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS09896 Oxtr Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Oxtr NCBI NCBI:5021
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