2. Gene
  3. FZD2 - frizzled class receptor 2 Gene

FZD2 - frizzled class receptor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：卷曲类受体 2

种属: Homo sapiens

同用名: Fz2; fz-2; fzE2; hFz2; OMOD2

基因 ID: 2535 | 基因类型: protein coding

关于 FZD2

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,557,484-44,561,262 (from NCBI)

This gene has 1 transcript (splice variant), 177 orthologues, 15 paralogues and is associated with 3 phenotypes.

功能概要

这种无内含子的基因是卷曲基因家族的成员。该家族的成员编码七次跨膜结构域蛋白，这些蛋白是无翼型 MMTV 整合位点信号蛋白家族的受体。该基因编码一种与 β-连环蛋白经典信号通路偶联的蛋白质。无翼型 MMTV 整合站点家族、成员 3A 和无翼型 MMTV 整合站点家族、成员 5A 基因产物之间用于结合该蛋白质的竞争被认为可调节 β-连环蛋白依赖性和非依赖性途径。[RefSeq 提供，2010 年 12 月]

This intronless gene is a member of the Frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]

FZD2 基因产物(1)

mRNA Protein Name
NM_001466.4 NP_001457.1 frizzled-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables PDZ domain binding IPI
IPI: 通过物理相互作用推断
19388021 GOA
enables Wnt receptor activity IDA
IDA: 通过直接分析推断
28733458 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25417160 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Wnt signaling pathway IMP
IMP: 通过突变表型推断
29276006 GOA
involved in canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
18215320 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
18929644 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18215320 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19038973 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
18929644 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FZD2 蛋白结构

Fz

Fz: Fz domain (39 - 150)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (234 - 557)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 565 a.a.
蛋白主名 其他名称

frizzled-2

frizzled 2, seven transmembrane spanning receptor

FZD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
FZD2 Q14332 tcdB Clostridium difficile M4NKV9
BLI
29748286
种属间
FZD2 Q14332 Fyn Mus musculus P39688
Peptide Array
25417160
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 FZD2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P78722 FZD2 Protein, Human (HEK293, Fc) Q14332 (Q24-P190) ≥95%

关联疾病

疾病名称 别名
Omodysplasia 2

OMOD2

Omodysplasia, Autosomal Dominant

Autosomal Dominant Omodysplasia

Omodysplasia Type 2

Omodysplasia, Type 2
Robinow Syndrome, Autosomal Dominant 2

Autosomal Dominant Robinow Syndrome 2

DRS2

Robinow, Autosomal Dominant Syndrome, Type 2
Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1

DRS1

Robinow Dwarfism

Fetal Face Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Robinow, Autosomal Dominant Syndrome, Type 1
Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome
Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive

Autosomal Recessive Robinow Syndrome

Covesdem Syndrome

RRS1

Costovertebral Segmentation Defect-Mesomelia Syndrome

Rrs

Costovertebral Segmentation Defect With Mesomelia, Formerly

Covesdem Syndrome, Formerly

Costovertebral Segmentation Defect With Mesomelia

Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly

Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals

Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly

Robinow, Autosomal Recessive Syndrome, Type 1
Autosomal Dominant Robinow Syndrome

Fetal Face Syndrome

Robinow Syndrome, Autosomal Dominant
Robinow Syndrome, Autosomal Dominant 3

Autosomal Dominant Robinow Syndrome 3

DRS3

Robinow, Autosomal Dominant Syndrome, Type 3
Omodysplasia

Omodysplasia Type 1

Omodysplasia 2
Midface Hypoplasia, Hearing Impairment, Elliptocytosis, And Nephrocalcinosis

MFHIEN
Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly

Fuhrmann Syndrome

Bowing Of The Femurs, Aplasia Or Hypoplasia Of The Fibula, And Digital Anomalies

Fibular Hypoplasia Or Aplasia-Femoral Bowing-Oligodactyly Syndrome

Fuhrmann-Rieger-De Sousa Syndrome

FUHRS

Fibular Aplasia

Hypoplasia Femoral Bowing And Poly- Syn- And Oligodactyly
Omodysplasia 1

OMOD1

Autosomal Recessive Omodysplasia

Omodysplasia Autosomal Recessive

Omodysplasia Generalized Form

Omodysplasia Type 1

Omodysplasia, Generalized Form

Omodysplasia, Autosomal Recessive

Micromelic Dysplasia, Congenital, With Dislocation Of Radius

Micromelic Dysplasia Congenita With Dislocation Of Radius

Micromelic Dysplasia-Dislocation Of Radius Syndrome

Micromelic Dysplasia Congenital With Dislocation Of Radius

Omodysplasia, Type 1
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Tetraamelia Syndrome

Tetra-Amelia Syndrome

Tetraamelia-Multiple Malformations Syndrome

Tetra-Amelia

Tetra-Amelia, Autosomal Recessive

Tetraamelia, Autosomal Recessive

Total Amelia

Zimmer Phocomelia

Tetams

Zimmer Taub Sova Syndrome
Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy

Fevr

Criswick-Schepens Syndrome

Exudative Vitreoretinopathy, Familial

Vitreoretinopathy, Exudative )

Exudative Vitreoretinopathy 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05178 FZD2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18359 Fzd2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24838 Fzd2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FZD2 VGNC VGNC:72834
Rattus norvegicus FZD2 RGD RGD:71012
Mus musculus FZD2 MGD MGI:1888513
Bos taurus FZD2 VGNC VGNC:29167
Felis catus FZD2 VGNC VGNC:62404
Canis familiaris FZD2 VGNC VGNC:41030
Others FZD2 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z