2. Gene
  3. Gabrb2 - gamma-aminobutyric acid type A receptor subunit beta 2 Gene

Gabrb2 - gamma-aminobutyric acid type A receptor subunit beta 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: GARB2

基因 ID: 25451 | 基因类型: protein coding

关于 Gabrb2

功能概要

Enables GABA-A receptor activity; Chloride Channel activity; and inhibitory extracellular ligand-gated ion channel activity. Contributes to GABA Receptor activity. Involved in GABAergic synaptic transmission; cellular response to histamine; and chloride transmembrane transport. Located in cytosol and membrane. Is integral component of plasma membrane. Part of GABA-A receptor complex. Human ortholog(s) of this gene implicated in autistic disorder and developmental and epileptic encephalopathy 92. Orthologous to human GABRB2 (gamma-aminobutyric acid type A receptor subunit beta2). [provided by Alliance of Genome Resources, Apr 2022]

Gabrb2 基因产物(1)

mRNA Protein Name
NM_012957.2 NP_037089.1 gamma-aminobutyric acid receptor subunit beta-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to GABA receptor activity IDA
IDA: 通过直接分析推断
12930820 RGD
enables GABA-A receptor activity IMP
IMP: 通过突变表型推断
11877425 RGD
enables chloride channel activity IMP
IMP: 通过突变表型推断
18281286 RGD
enables inhibitory extracellular ligand-gated monoatomic ion channel activity IMP
IMP: 通过突变表型推断
11877425 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
IDA: 通过直接分析推断
26592470 RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
IMP: 通过突变表型推断
26592470 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11350968 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to histamine IDA
IDA: 通过直接分析推断
18281286 RGD
involved in chloride transmembrane transport IMP
IMP: 通过突变表型推断
18281286 RGD
involved in synaptic transmission, GABAergic IDA
IDA: 通过直接分析推断
12930820 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of GABA receptor complex IDA
IDA: 通过直接分析推断
12930820 RGD
part of GABA-A receptor complex IMP
IMP: 通过突变表型推断
18281286 RGD
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
15174078 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
15174078 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
9464994 RGD
located in plasma membrane IMP
IMP: 通过突变表型推断
18281286 RGD
is active in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
15174078 RGD
located in postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
9464994 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
15174078 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

gamma-aminobutyric acid receptor subunit beta-2

GABA(A) receptor subunit beta-2

Gamma-aminobutyric acid receptor beta 2

gamma-aminobutyric acid (GABA) A receptor, beta 2

gamma-aminobutyric acid (GABA-A) receptor, subunit beta 2

gamma-aminobutyric acid type A receptor beta 2 subunit

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05216 GABRB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21133 Gabrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27651 Gabrb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gabrb2 NCBI NCBI:2561
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