2. Gene
  3. Npm1 - nucleophosmin 1 Gene

Npm1 - nucleophosmin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: B23NP

基因 ID: 25498 | 基因类型: protein coding

关于 Npm1

功能概要

Enables several functions, including anion binding activity; p53 binding activity; and protein kinase B binding activity. Involved in several processes, including RNA metabolic process; negative regulation of apoptotic process; and regulation of DNA replication. Located in cytoplasm and nuclear lumen. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Apr 2022]

Npm1 基因产物(1)

mRNA Protein Name
NM_012992.4 NP_037124.1 nucleophosmin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IMP
IMP: 通过突变表型推断
19123973 RGD
enables DNA binding IDA
IDA: 通过直接分析推断
8611572 RGD
enables enzyme binding IDA
IDA: 通过直接分析推断
11481036 RGD
enables enzyme binding IPI
IPI: 通过物理相互作用推断
15893727 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
8611572 RGD
enables p53 binding IPI
IPI: 通过物理相互作用推断
15872011 RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding IPI
IPI: 通过物理相互作用推断
15893727 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10220582 RGD
enables protein kinase B binding IDA
IDA: 通过直接分析推断
18931307 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac muscle hypertrophy IEP
IEP: 通过表达模式推断
21444791 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
21444791 RGD
involved in cellular response to testosterone stimulus IEP
IEP: 通过表达模式推断
8287071 RGD
involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IDA
IDA: 通过直接分析推断
9742256 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
14635188 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
21444791 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
15872011 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
19123973 RGD
involved in positive regulation of DNA metabolic process IDA
IDA: 通过直接分析推断
11481036 RGD
involved in positive regulation of DNA replication IDA
IDA: 通过直接分析推断
11481036 RGD
involved in positive regulation of DNA-directed DNA polymerase activity IDA
IDA: 通过直接分析推断
8123045 RGD
involved in positive regulation of catalytic activity IDA
IDA: 通过直接分析推断
11481036 RGD
involved in rRNA transcription IMP
IMP: 通过突变表型推断
21444791 RGD
involved in regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
15893727 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear matrix IDA
IDA: 通过直接分析推断
20387789 RGD
located in nucleoplasm IDA
IDA: 通过直接分析推断
14635188 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nucleophosmin

NPM

nucleolar phosphoprotein B23

nucleolar protein B23.1

nucleolar protein NO38

nucleophosmin (nucleolar phosphoprotein B23, numatrin)

numatrin

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-136360 MI-3454 Inhibitor 98.03% 否
HY-162265A UCM-13369 dihydrochloride Inducer 99.87% 否
HY-N10264 Avrainvillamide 95.00% 否
HY-162265 UCM-13369 Inducer / 否
HY-164279 YTR107 / 否
HY-114162B VTP50469 mesylate / 否
HY-E70760 NPM1 ALK Recombinant Human Active Protein Kinase / 否
HY-E70761 NPM1 ALK F1174L Recombinant Human Active Protein Kinase / 否
HY-RS09490 NPM1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17071 Npm1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18762 Gja1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23515 Npm1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Npm1 NCBI NCBI:4869
Mus musculus Npm1 NCBI NCBI:18148
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