2. Gene
  3. Fn1 - fibronectin 1 Gene

Fn1 - fibronectin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: fn-1; FIBNEC

基因 ID: 25661 | 基因类型: protein coding

关于 Fn1

功能概要

Enables mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mercury ion; and cellular response to peptide. Located in basement membrane and extracellular space. Used to study diabetic angiopathy; hypertension; and renovascular hypertension. Biomarker of several diseases, including artery disease (multiple); calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fn1 基因产物(1)

mRNA Protein Name
NM_019143.2 NP_062016.2 fibronectin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mercury ion binding IDA
IDA: 通过直接分析推断
11768240 RGD
enables protease binding IPI
IPI: 通过物理相互作用推断
18039280 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10640397 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-matrix adhesion IMP
IMP: 通过突变表型推断
12388756 RGD
involved in cellular response to BMP stimulus IEP
IEP: 通过表达模式推断
12619935 RGD
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
11698153 RGD
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
20942814 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
22732364 RGD
involved in cellular response to interleukin-1 IMP
IMP: 通过突变表型推断
12679595 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
11819312 RGD
involved in cellular response to mercury ion IDA
IDA: 通过直接分析推断
11768240 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: 通过表达模式推断
15627306 RGD
involved in cellular response to prostaglandin E stimulus IEP
IEP: 通过表达模式推断
15833739 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
16669970 RGD
involved in cellular response to vascular endothelial growth factor stimulus IEP
IEP: 通过表达模式推断
23269647 RGD
involved in extracellular matrix organization IMP
IMP: 通过突变表型推断
12388756 RGD
involved in glial cell migration IDA
IDA: 通过直接分析推断
19172391 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
15677310 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: 通过突变表型推断
15980055 RGD
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
10634931 RGD
involved in positive regulation of chemotaxis IDA
IDA: 通过直接分析推断
11456126 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
23383330 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
15539768 RGD
involved in response to iron ion IEP
IEP: 通过表达模式推断
18723004 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
12482021 RGD
involved in response to ozone IEP
IEP: 通过表达模式推断
9700094 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
23383330 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basement membrane IDA
IDA: 通过直接分析推断
14656002 RGD
located in extracellular space IDA
IDA: 通过直接分析推断
11352844 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

fibronectin

FN

fibronectin 2

fibronectin 3

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138657 NCGC00378430 Inhibitor 99.58% 否
HY-RS05013 FN1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16767 Fn1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23207 Fn1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fn1 NCBI NCBI:2335
Mus musculus Fn1 NCBI NCBI:14268
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