2. Gene
  3. GABRP - gamma-aminobutyric acid type A receptor subunit pi Gene

GABRP - gamma-aminobutyric acid type A receptor subunit pi Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：γ-氨基丁酸 A 型受体亚基 pi

种属: Homo sapiens

基因 ID: 2568 | 基因类型: protein coding

关于 GABRP

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,782,720-170,814,047 (from NCBI)

This gene has 10 transcripts (splice variants), 124 orthologues and 45 paralogues. Biased expression in esophagus (RPKM 45.1), endometrium (RPKM 30.6) and 5 other tissues.

功能概要

γ-氨基丁酸 (GABA) A 受体是一种多亚基氯离子通道，可介导中枢神经系统中最快的抑制性突触传递。由该基因编码的亚基在几种非神经元组织中表达，包括子宫和卵巢。该亚基可以与已知的 GABA A 受体亚基组装，并且该亚基的存在会改变重组受体对孕烯醇酮等调节剂的敏感性。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2014 年 5 月]

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit Chloride Channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

GABRP 基因产物(2)

mRNA Protein Name
NM_001291985.2 NP_001278914.1 gamma-aminobutyric acid receptor subunit pi isoform 2 precursor
NM_014211.3 NP_055026.1 gamma-aminobutyric acid receptor subunit pi isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GABA-A receptor activity IDA
IDA: 通过直接分析推断
10462548 GOA
enables GABA-gated chloride ion channel activity IDA
IDA: 通过直接分析推断
10462548 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GABRP 蛋白结构

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (42 - 241)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (249 - 356)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
蛋白主名 其他名称

gamma-aminobutyric acid receptor subunit pi

GABA(A) receptor subunit pi

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05223 GABRP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20412 Gabrp Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26921 Gabrp Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GABRP MGD MGI:2387597
Rattus norvegicus GABRP RGD RGD:620532
Macaca mulatta GABRP VGNC VGNC:72859
Felis catus GABRP VGNC VGNC:62428
Bos taurus GABRP VGNC VGNC:29201
Canis familiaris GABRP VGNC VGNC:41065
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