2. Gene
  3. Hmbs - hydroxymethylbilane synthase Gene

Hmbs - hydroxymethylbilane synthase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: PBGD; hemC; PBG-D; URO-S

基因 ID: 25709 | 基因类型: protein coding

关于 Hmbs

功能概要

Enables several functions, including amine binding activity; hydroxymethylbilane synthase activity; and uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to lead ion; and response to estradiol. Located in several cellular components, including axon; cytosol; and perinuclear region of cytoplasm. Colocalizes with condensed chromosome. Biomarker of bilirubin metabolic disorder and liver carcinoma. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase). [provided by Alliance of Genome Resources, Apr 2022]

Hmbs 基因产物(1)

mRNA Protein Name
NM_013168.2 NP_037300.2 porphobilinogen deaminase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amine binding IPI
IPI: 通过物理相互作用推断
9344466 RGD
enables carboxylic acid binding IPI
IPI: 通过物理相互作用推断
9344466 RGD
enables hydroxymethylbilane synthase activity IDA
IDA: 通过直接分析推断
593266 RGD
enables hydroxymethylbilane synthase activity IMP
IMP: 通过突变表型推断
18760440 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12917623 RGD
enables uroporphyrinogen-III synthase activity IDA
IDA: 通过直接分析推断
6466301 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
2886336 RGD
involved in astrocyte differentiation IEP
IEP: 通过表达模式推断
12917623 RGD
involved in cellular response to amine stimulus IEP
IEP: 通过表达模式推断
10416273 RGD
involved in cellular response to antibiotic IEP
IEP: 通过表达模式推断
19688726 RGD
involved in cellular response to arsenic-containing substance IEP
IEP: 通过表达模式推断
10416273 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
4019471 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
7917467 RGD
involved in cellular response to lead ion IEP
IEP: 通过表达模式推断
16566714 RGD
involved in liver development IDA
IDA: 通过直接分析推断
971328 RGD
involved in porphyrin-containing compound biosynthetic process IDA
IDA: 通过直接分析推断
971328 RGD
involved in porphyrin-containing compound metabolic process IDA
IDA: 通过直接分析推断
593266 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
8295845 RGD
involved in response to carbohydrate IEP
IEP: 通过表达模式推断
17285311 RGD
involved in response to cobalt ion IEP
IEP: 通过表达模式推断
6688350 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
10416826 RGD
involved in response to hormone IEP
IEP: 通过表达模式推断
9468112 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
3697363 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
16566714 RGD
involved in response to metal ion IEP
IEP: 通过表达模式推断
4040350 RGD
involved in response to methylmercury IEP
IEP: 通过表达模式推断
3327437 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
8000239 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
3580703 RGD
involved in response to vitamin IEP
IEP: 通过表达模式推断
9559098 RGD
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
6893114 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
10571258 RGD
involved in response to zinc ion IEP
IEP: 通过表达模式推断
8582750 RGD
involved in tetrapyrrole biosynthetic process IDA
IDA: 通过直接分析推断
6712591 RGD
involved in tetrapyrrole biosynthetic process IMP
IMP: 通过突变表型推断
18760440 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
11202056 RGD
located in condensed chromosome IDA
IDA: 通过直接分析推断
12917623 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
11202056 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

porphobilinogen deaminase

alternative name: porphobilinogen deaminase

pre-uroporphyrinogen synthase

uroporphyrinogen I synthase

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119524 Clofibride / 否
HY-137281 HMB-Val-Ser-Leu-VE Inhibitor / 否
HY-RS06224 HMBS Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18945 Hmbs Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25435 Hmbs Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hmbs NCBI NCBI:3145
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