2. Gene
  3. SLC24A2 - solute carrier family 24 member 2 Gene

SLC24A2 - solute carrier family 24 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 24 成员 2

种属: Homo sapiens

同用名: NCKX2

基因 ID: 25769 | 基因类型: protein coding

关于 SLC24A2

Cytogenetic location: 9p22.1-p21.3 Genomic coordinates (GRCh38): 9:19,507,455-20,307,892 (from NCBI)

This gene has 2 transcripts (splice variants), 288 orthologues and 4 paralogues. Restricted expression toward brain (RPKM 17.5).

功能概要

该基因编码转运蛋白钙/阳离子反向转运蛋白超家族的成员。编码的蛋白属于交换器的 SLC24 分支，可以介导一个 Ca2+离子和一个 K+离子的挤出以交换四个 Na+离子。该家族成员是一种视网膜锥体/脑交换器，可介导光诱导的游离 Ca2+ 浓度降低。这种蛋白质也可能在缺血性脑损伤期间发挥神经保护作用。可变剪接导致多个转录本变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

SLC24A2 基因产物(4)

mRNA Protein Name
NM_001193288.3 NP_001180217.1 sodium/potassium/calcium exchanger 2 isoform 2
NM_001375850.1 NP_001362779.1 sodium/potassium/calcium exchanger 2 isoform 1
NM_001375851.1 NP_001362780.1 sodium/potassium/calcium exchanger 2 isoform 2
NM_020344.4 NP_065077.1 sodium/potassium/calcium exchanger 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium, potassium:sodium antiporter activity IDA
IDA: 通过直接分析推断
10662833 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium ion import IDA
IDA: 通过直接分析推断
27093457 GOA
involved in calcium ion import across plasma membrane IDA
IDA: 通过直接分析推断
10662833 GOA
involved in calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
26631410 GOA
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
26631410 GOA
acts upstream of or within monoatomic ion transmembrane transport IDA
IDA: 通过直接分析推断
18166528 GOA
involved in potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
26631410 GOA
involved in sodium ion transmembrane transport IDA
IDA: 通过直接分析推断
26631410 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
26631410 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC24A2 蛋白结构

Na_Ca_ex

Na_Ca_ex: Sodium/calcium exchanger protein (149 - 279)

Na_Ca_ex

Na_Ca_ex: Sodium/calcium exchanger protein (509 - 646)

  • 0
  • 200
  • 400
  • 600
  • 661 a.a.
蛋白主名 其他名称

sodium/potassium/calcium exchanger 2

Na(+)/K(+)/Ca(2+)-exchange protein 2

关联疾病

疾病名称 别名
Epilepsy, Familial Temporal Lobe, 5

Familial Temporal Lobe Epilepsy 5

ETL5

Epilepsy, Temporal Lobe, Familial, Type 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13085 SLC24A2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS13087 SLC24A4 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC24A2 RGD RGD:628650
Mus musculus SLC24A2 MGD MGI:1923626
Macaca mulatta SLC24A2 VGNC VGNC:77425
Felis catus SLC24A2 VGNC VGNC:65249
Bos taurus SLC24A2 VGNC VGNC:34737
Canis familiaris SLC24A2 VGNC VGNC:46286
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