2. Gene
  3. PRKD2 - protein kinase D2 Gene

PRKD2 - protein kinase D2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 D2

种属: Homo sapiens

同用名: PKD2; HSPC187; nPKC-D2

基因 ID: 25865 | 基因类型: protein coding

关于 PRKD2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:46,674,316-46,717,114 (from NCBI)

This gene has 17 transcripts (splice variants), 190 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 19.7), lymph node (RPKM 14.5) and 25 other tissues.

功能概要

该基因编码的蛋白质属于丝氨酸/苏氨酸蛋白激酶的蛋白激酶 D (PKD) 家族。这种激酶可以被佛波醇酯以及胃泌素通过胃癌细胞中的胆囊收缩素 B 受体 (CCKBR) 激活。它可以与反式高尔基体网络 (TGN) 中的二酰甘油 (DAG) 结合，并可能调节基底外侧膜蛋白从 TGN 中退出。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by Gastrin via the cholecystokinin B receptor (CCKBR) in gastric Cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PRKD2 基因产物(4)

mRNA Protein Name
NM_001079880.2 NP_001073349.1 serine/threonine-protein kinase D2 isoform A
NM_001079881.2 NP_001073350.1 serine/threonine-protein kinase D2 isoform A
NM_001079882.2 NP_001073351.1 serine/threonine-protein kinase D2 isoform B
NM_016457.5 NP_057541.2 serine/threonine-protein kinase D2 isoform A

PRKD2 蛋白结构

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (139 - 189)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (265 - 314)

PH

PH: PH domain (400 - 477)

Pkinase

Pkinase: Protein kinase domain (555 - 807)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 878 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase D2

重组 PRKD2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74615 Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) Q9BZL6-1 (M1-L878) ≥95%

关联疾病

疾病名称 别名
Angiolipoma
Conventional Lipoma

Classic Type Lipoma
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11147 PRKD2 Human Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRKD2 MGD MGI:2141917
Macaca mulatta PRKD2 VGNC VGNC:76273
Bos taurus PRKD2 VGNC VGNC:33337
Canis familiaris PRKD2 VGNC VGNC:44987
Felis catus PRKD2 VGNC VGNC:64356
Rattus norvegicus PRKD2 RGD RGD:1308054
Others PRKD2 NCBI
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