2. Gene
  3. MRGPRX1 - MAS related GPR family member X1 Gene

MRGPRX1 - MAS related GPR family member X1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MAS 相关 GPR 家族成员 X1

种属: Homo sapiens

同用名: GPCR; MGRG2; MRGX1; SNSR4

基因 ID: 259249 | 基因类型: protein coding

关于 MRGPRX1

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,933,499-18,939,414 (from NCBI)

This gene has 2 transcripts (splice variants), 440 orthologues and 10 paralogues.

功能概要

启用跨膜信号受体活性。参与细胞表面受体信号通路和对氯喹的反应。预测位于细胞表面。 [由基因组资源联盟提供，2022 年 4 月]

Enables transmembrane signaling receptor activity. Involved in cell surface receptor signaling pathway and response to chloroquine. Predicted to be located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]

MRGPRX1 基因产物(2)

mRNA Protein Name
NM_001393578.1 NP_001380507.1 mas-related G-protein coupled receptor member X1
NM_147199.4 NP_671732.3 mas-related G-protein coupled receptor member X1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transmembrane signaling receptor activity IMP
IMP: 通过突变表型推断
20004959 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
20004959 GOA
involved in response to chloroquine IMP
IMP: 通过突变表型推断
20004959 GOA
involved in signal transduction IMP
IMP: 通过突变表型推断
26582731 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MRGPRX1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 272)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
蛋白主名 其他名称

mas-related G-protein coupled receptor member X1

G protein-coupled receptor MRGX1

关联疾病

疾病名称 别名
Neurodermatitis
Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus

Diabetes Insipidus, Nephrogenic

Diabetes Insipidus Nephrogenic

Congenital Nephrogenic Diabetes Insipidus

Adh Resistant Diabetes Insipidus

Diabetes Insipidus Nephrogenic X-Linked

Diabetes Insipidus Nephrogenic Type 1

Adh-Resistant Diabetes Insipidus

Diabetes Insipidus Renalis

Ndi

Renal Diabetes Insipidus

Familial Nephrogenic Diabetes

Antidiuretic-Hormone-Resistant Diabetes Insipidus

Adiuretin-Resistant Diabetes Insipidus

Ndi - [Nephrogenic Diabetes Insipidus]

Diabetes Tenuifluus

Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

Hereditary Nephrogenic Diabetes Insipidus

Familial Nephrogenic Diabetes Insipidus

Primary Nephrogenic Diabetes Insipidus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-130118 MRGPRX1 agonist 1 Agonist 99.95% 否
HY-110285 ML382 99.89% 否
HY-143878 MRGPRX1 agonist 2 Agonist / 否
HY-143879 MRGPRX1 agonist 3 Agonist / 否
HY-143880 MRGPRX1 agonist 4 Agonist / 否
HY-173003 EP-3945 Agonist / 否
HY-RS08650 MRGPRX1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17519 Mrgprx1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-W242735 4-Aminobenzimidamide Hydrochloride Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MRGPRX1 RGD RGD:1591915
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