2. Gene
  3. TIPARP - TCDD inducible poly(ADP-ribose) polymerase Gene

TIPARP - TCDD inducible poly(ADP-ribose) polymerase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：TCDD 诱导型聚 (ADP-核糖) 聚合酶

种属: Homo sapiens

同用名: PARP7; ARTD14; pART14

基因 ID: 25976 | 基因类型: protein coding

关于 TIPARP

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:156,674,590-156,706,770 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 8 paralogues. Ubiquitous expression in adrenal (RPKM 28.8), esophagus (RPKM 23.5) and 24 other tissues.

功能概要

该基因编码聚 (ADP-核糖) 聚合酶超家族的成员。对小鼠直系同源物的研究表明，编码的蛋白质催化组蛋白聚 (ADP-核糖基) 化，并可能参与 T 细胞功能。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of the poly(ADP-ribose) polymerase superfamily. Studies of the mouse ortholog have shown that the encoded protein catalyzes histone poly(ADP-ribosyl)ation and may be involved in T-cell function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

TIPARP 基因产物(6)

mRNA Protein Name
NM_001184717.1 NP_001171646.1 protein mono-ADP-ribosyltransferase TIPARP
XM_047447935.1 XP_047303891.1 protein mono-ADP-ribosyltransferase TIPARP isoform X1
XM_047447936.1 XP_047303892.1 protein mono-ADP-ribosyltransferase TIPARP isoform X2
NM_001184718.2 NP_001171647.1 protein mono-ADP-ribosyltransferase TIPARP
NM_015508.5 NP_056323.2 protein mono-ADP-ribosyltransferase TIPARP
XM_047447937.1 XP_047303893.1 protein mono-ADP-ribosyltransferase TIPARP isoform X2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
23275542 GOA
enables NAD+-protein-cysteine ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
30373764 GOA
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23275542 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: 通过直接分析推断
23275542 GOA
acts upstream of or within negative regulation of gene expression IMP
IMP: 通过突变表型推断
23275542 GOA
acts upstream of or within positive regulation of protein catabolic process IMP
IMP: 通过突变表型推断
23275542 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
23275542 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TIPARP 蛋白结构

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (466 - 649)

  • 0
  • 200
  • 400
  • 600
  • 657 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase TIPARP

ADP-ribosyltransferase diphtheria toxin-like 14

poly [ADP-ribose] polymerase 7

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14546 TIPARP Human Pre-designed siRNA Set A / 否
HY-RS14547 Tiparp Mouse Pre-designed siRNA Set A / 否
HY-RS14548 Tiparp Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TIPARP VGNC VGNC:53609
Mus musculus TIPARP MGD MGI:2159210
Macaca mulatta TIPARP VGNC VGNC:82714
Felis catus TIPARP VGNC VGNC:102854
Canis familiaris TIPARP VGNC VGNC:52906
Rattus norvegicus TIPARP RGD RGD:1306171
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