2. Gene
  3. HINFP - histone H4 transcription factor Gene

HINFP - histone H4 transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：组蛋白 H4 转录因子

种属: Homo sapiens

同用名: MIZF; HiNF-P; ZNF743

基因 ID: 25988 | 基因类型: protein coding

关于 HINFP

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,121,580-119,136,059 (from NCBI)

This gene has 14 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in testis (RPKM 6.2), lymph node (RPKM 4.3) and 25 other tissues.

功能概要

该基因编码的转录因子与甲基 CpG 结合蛋白 2 (MBD2) 相互作用，MBD2 是 MeCP1 组蛋白脱乙酰酶 (HDAC) 复合物的一个组成部分，在 DNA 甲基化和转录抑制中发挥作用。已发现该基因的可变剪接转录本变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]

HINFP 基因产物(17)

mRNA Protein Name
NM_001243259.2 NP_001230188.1 histone H4 transcription factor isoform 2
NM_001351957.2 NP_001338886.1 histone H4 transcription factor isoform 3
NM_001351958.2 NP_001338887.1 histone H4 transcription factor isoform 1
NM_001351959.2 NP_001338888.1 histone H4 transcription factor isoform 1
NM_001351960.2 NP_001338889.1 histone H4 transcription factor isoform 1
NM_001351961.2 NP_001338890.1 histone H4 transcription factor isoform 4
NM_001351962.2 NP_001338891.1 histone H4 transcription factor isoform 4
NM_001351963.2 NP_001338892.1 histone H4 transcription factor isoform 5
NM_001351964.2 NP_001338893.1 histone H4 transcription factor isoform 5
NM_001351965.2 NP_001338894.1 histone H4 transcription factor isoform 6
NM_001351966.2 NP_001338895.1 histone H4 transcription factor isoform 6
NM_001351969.2 NP_001338898.1 histone H4 transcription factor isoform 6
NM_001351971.2 NP_001338900.1 histone H4 transcription factor isoform 6
NM_001351972.2 NP_001338901.1 histone H4 transcription factor isoform 6
NM_001351974.2 NP_001338903.1 histone H4 transcription factor isoform 6
NM_015517.5 NP_056332.2 histone H4 transcription factor isoform 1
NM_198971.3 NP_945322.1 histone H4 transcription factor isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9540062 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
18850719 GOA
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
9540062 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18850719 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
11553631 GOA
enables histone binding IPI
IPI: 通过物理相互作用推断
9540062 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11553631 GOA
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
14752047 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage checkpoint signaling IMP
IMP: 通过突变表型推断
17974976 GOA
involved in DNA repair IMP
IMP: 通过突变表型推断
17974976 GOA
involved in G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
14585971 GOA
involved in cell cycle G1/S phase transition IMP
IMP: 通过突变表型推断
15988025 GOA
involved in establishment of protein localization IMP
IMP: 通过突变表型推断
15988025 GOA
involved in myoblast differentiation IMP
IMP: 通过突变表型推断
15541338 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11553631 GOA
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
15541338 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14585971 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
14585971 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18850719 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
9540062 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
15988025 GOA
NOT located in nucleolus IDA
IDA: 通过直接分析推断
11553631 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
11553631 GOA
located in nucleus IDA
IDA: 通过直接分析推断
14585971 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HINFP 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (186 - 210)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (229 - 251)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (255 - 278)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (345 - 368)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 517 a.a.
蛋白主名 其他名称

histone H4 transcription factor

MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein

关联疾病

疾病名称 别名
Cerebrooculofacioskeletal Syndrome 2

COFS2

Cerebro-Oculo-Facio-Skeletal Syndrome 2

Cofs Syndrome
Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome
Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability

Non-Specific X-Linked Mental Retardation

X-Linked Non-Specific Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06175 HINFP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22553 Hinfp Mouse Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HINFP RGD RGD:1311492
Canis familiaris HINFP VGNC VGNC:50633
Mus musculus HINFP MGD MGI:2429620
Macaca mulatta HINFP VGNC VGNC:73408
Bos taurus HINFP VGNC VGNC:50615
Felis catus HINFP VGNC VGNC:62816
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