2. Gene
  3. REXO2 - RNA exonuclease 2 Gene

REXO2 - RNA exonuclease 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RNA 核酸外切酶 2

种属: Homo sapiens

同用名: RFN; SFN; REX2; CGI-114

基因 ID: 25996 | 基因类型: protein coding

关于 REXO2

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:114,439,467-114,450,279 (from NCBI)

This gene has 19 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in heart (RPKM 41.6), kidney (RPKM 38.9) and 25 other tissues.

功能概要

该基因编码一种 3'-to-5' 核酸外切酶，专用于小 (长度主要为 5 个核苷酸或更短) 单链 RNA 和 DNA 寡聚体。这种蛋白质可能在 DNA 修复、复制和重组以及 RNA 加工和降解中发挥作用。它还可能通过其在 DNA 修复过程中的作用参与人体细胞对 UV-C 诱导的细胞死亡的抵抗。[RefSeq 提供，2011 年 11 月]

This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]

REXO2 基因产物(1)

mRNA Protein Name
NM_015523.4 NP_056338.2 oligoribonuclease, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5' exonuclease activity IDA
IDA: 通过直接分析推断
10851236 GOA
enables 3'-5' exonuclease activity IMP
IMP: 通过突变表型推断
23741365 GOA
enables 3'-5'-DNA exonuclease activity IDA
IDA: 通过直接分析推断
31588022 GOA
enables 3'-5'-RNA exonuclease activity IDA
IDA: 通过直接分析推断
31588022 GOA
enables 3'-5'-RNA exonuclease activity IMP
IMP: 通过突变表型推断
30926754 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
30926754 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within nucleobase-containing compound metabolic process IDA
IDA: 通过直接分析推断
10851236 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
32365187 GOA
located in mitochondrial intermembrane space IDA
IDA: 通过直接分析推断
23741365 GOA
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
23741365 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
32365187 GOA
located in nucleus IDA
IDA: 通过直接分析推断
32365187 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

REXO2 蛋白结构

RNase_T

RNase_T: Exonuclease (44 - 206)

  • 0
  • 100
  • 200
  • 237 a.a.
蛋白主名 其他名称

oligoribonuclease, mitochondrial

REX2, RNA exonuclease 2 homolog

关联疾病

疾病名称 别名
Gallbladder Melanoma

Malignant Melanoma Of Gallbladder
Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11864 REXO2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS20094 Rexo2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26597 Rexo2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus REXO2 VGNC VGNC:64581
Macaca mulatta REXO2 VGNC VGNC:76757
Mus musculus REXO2 MGD MGI:1888981
Rattus norvegicus REXO2 RGD RGD:1304874
Canis familiaris REXO2 VGNC VGNC:45490
Bos taurus REXO2 VGNC VGNC:33884
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