2. Gene
  3. RNF167 - ring finger protein 167 Gene

RNF167 - ring finger protein 167 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 167

种属: Homo sapiens

同用名: LP2254; RING105; 5730408C10Rik

基因 ID: 26001 | 基因类型: protein coding

关于 RNF167

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,940,092-4,945,222 (from NCBI)

This gene has 16 transcripts (splice variants), 121 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 26.0), thyroid (RPKM 24.0) and 25 other tissues.

功能概要

RNF167 是一种 E3 泛素连接酶，与 TSSC5 (SLC22A18；MIM 602631) 相互作用，并与 UBCH6 (UBE2E1；MIM 602916) 一起促进 TSSC5 多泛素化 (Yamada 和 Gorbsky，2006 [PubMed 16314844]) 。[OMIM 提供，2008 年 3 月] ]

RNF167 is an E3 ubiquitin Ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

RNF167 基因产物(20)

mRNA Protein Name
NM_001320356.2 NP_001307285.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320357.2 NP_001307286.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320358.2 NP_001307287.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320359.2 NP_001307288.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320360.2 NP_001307289.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320361.2 NP_001307290.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001320362.2 NP_001307291.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320363.2 NP_001307292.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320364.2 NP_001307293.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001320365.2 NP_001307294.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001370303.1 NP_001357232.1 E3 ubiquitin-protein ligase RNF167 isoform c precursor
NM_001370304.1 NP_001357233.1 E3 ubiquitin-protein ligase RNF167 isoform c precursor
NM_001370305.1 NP_001357234.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_001370306.1 NP_001357235.1 E3 ubiquitin-protein ligase RNF167 isoform d precursor
NM_001370307.1 NP_001357236.1 E3 ubiquitin-protein ligase RNF167 isoform d precursor
NM_001370308.1 NP_001357237.1 E3 ubiquitin-protein ligase RNF167 isoform e
NM_001370311.1 NP_001357240.1 E3 ubiquitin-protein ligase RNF167 isoform b
NM_001370313.1 NP_001357242.1 E3 ubiquitin-protein ligase RNF167 isoform f precursor
NM_001375485.1 NP_001362414.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
NM_015528.3 NP_056343.1 E3 ubiquitin-protein ligase RNF167 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16314844 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
23129617 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
16314844 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to leucine starvation IDA
IDA: 通过直接分析推断
35114100 GOA
acts upstream of lysosome localization IDA
IDA: 通过直接分析推断
32409562 GOA
involved in lysosome localization IDA
IDA: 通过直接分析推断
27808481 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
35114100 GOA
involved in negative regulation of cell cycle IMP
IMP: 通过突变表型推断
16314844 GOA
involved in organelle localization IMP
IMP: 通过突变表型推断
24387786 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: 通过直接分析推断
33594058 GOA
involved in protein K29-linked ubiquitination IDA
IDA: 通过直接分析推断
33594058 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
35114100 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
16314844 GOA
involved in regulation of synaptic transmission, glutamatergic IDA
IDA: 通过直接分析推断
23129617 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: 通过直接分析推断
27808481 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16314844 GOA
is active in cytosol IDA
IDA: 通过直接分析推断
32409562 GOA
is active in endolysosome membrane IDA
IDA: 通过直接分析推断
23129617 GOA
located in endosome IDA
IDA: 通过直接分析推断
24387786 GOA
is active in lysosomal membrane IDA
IDA: 通过直接分析推断
27808481 GOA
is active in lysosome IDA
IDA: 通过直接分析推断
27808481 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF167 蛋白结构

PA

PA: PA domain (52 - 150)

zf-RING_2

zf-RING_2: Ring finger domain (228 - 272)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF167

RING-type E3 ubiquitin transferase RNF167

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 73

DEE73

Epileptic Encephalopathy, Early Infantile, 73

Eiee73

Developmental And Epileptic Encephalopathy, 73

Early Infantile Epileptic Encephalopathy 73

Rnf13-Related Severe Early-Onset Epileptic Encephalopathy

Rnf13-Related Severe Eoee
Lissencephaly 8

LIS8
Spinocerebellar Ataxia, Autosomal Recessive 24

SCAR24

Autosomal Recessive Spinocerebellar Ataxia 24

Spinocerebellar Ataxia, Autosomal Recessive, 24

Ataxia, Spinocerebellar, Autosomal Recessive, Type 24
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12061 RNF167 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RNF167 VGNC VGNC:76812
Mus musculus RNF167 MGD MGI:1917760
Rattus norvegicus RNF167 RGD RGD:1305972
Canis familiaris RNF167 VGNC VGNC:59031
Bos taurus RNF167 VGNC VGNC:57151
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