Esrra - estrogen related receptor, alpha Gene

中文名称：雌激素相关受体， α

种属: Mus musculus

同用名: Err1; Nr3b1; Estrra; ERRalpha

关于 Esrra

功能概要

该基因编码的蛋白可启动 DNA 结合转录激活剂活性，RNA 聚合酶 II 特异性； DNA 结合转录抑制活性，RNA 聚合酶 II 特异性；和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与 RNA 聚合酶 II 对转录的负调控。在 RNA 聚合酶 II 的转录正调控上游或正调控内起作用。位于核内。以多种结构表达，包括消化系统；泌尿生殖系统；心;神经系统;和感觉器官。与人类 ESRRA（雌激素相关受体 α）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human ESRRA (estrogen related receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]