Esrrb - estrogen related receptor, beta Gene

中文名称：雌激素相关受体， β

种属: Mus musculus

同用名: Err2; Errb; Nr3b2; Estrrb

关于 Esrrb

功能概要

该基因编码的蛋白可启动 DNA 结合转录激活剂活性，RNA 聚合酶 II 特异性； RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；和 RNA 聚合酶 II 复合物结合活性。参与多个过程，包括光感受器细胞维护；干细胞群维持的正向调节；和调节细胞大分子生物合成过程。通过 RNA 聚合酶 II 在子宫内胚胎发育和转录的正调控中发挥作用。位于浓缩染色体；细胞质；和核。积分复合体的一部分。以多种结构表达，包括中枢神经系统；早孕;内分泌腺;性腺;和感觉器官。用于研究扩张型心肌病。该基因的人类直向同源基因与常染色体隐性遗传性非综合征性耳聋 35 相关。与人类 ESRRB（雌激素相关受体 β）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II complex binding activity. Involved in several processes, including photoreceptor cell maintenance; positive regulation of stem cell population maintenance; and regulation of cellular macromolecule biosynthetic process. Acts upstream of or within in utero embryonic development and positive regulation of transcription by RNA polymerase II. Located in condensed chromosome; cytoplasm; and nucleus. Part of integrator complex. Is expressed in several structures, including central nervous system; early conceptus; endocrine gland; gonad; and sensory organ. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 35. Orthologous to human ESRRB (estrogen related receptor beta). [provided by Alliance of Genome Resources, Apr 2022]