2. Gene
  3. NR6A1 - nuclear receptor subfamily 6 group A member 1 Gene

NR6A1 - nuclear receptor subfamily 6 group A member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核受体亚科 6 组 A 成员 1

种属: Homo sapiens

同用名: RTR; GCNF; NR61; hRTR; CT150; GCNF1; hGCNF

基因 ID: 2649 | 基因类型: protein coding

关于 NR6A1

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,517,275-124,771,311 (from NCBI)

This gene has 5 transcripts (splice variants) and 227 orthologues. Biased expression in testis (RPKM 11.0), thyroid (RPKM 1.5) and 7 other tissues.

功能概要

该基因编码一个孤儿核受体，它是核激素受体家族的一员。其表达模式表明它可能参与神经发生和生殖细胞发育。该蛋白质可以同源二聚化并结合 DNA，但体内靶标尚未确定。交替剪接导致多个转录变体。[RefSeq 提供，2013 年 6 月]

This gene encodes an Orphan Nuclear Receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

NR6A1 基因产物(4)

mRNA Protein Name
NM_001278546.2 NP_001265475.1 nuclear receptor subfamily 6 group A member 1 isoform 4
NM_001410996.1 NP_001397925.1 nuclear receptor subfamily 6 group A member 1 isoform 5
NM_001489.5 NP_001480.3 nuclear receptor subfamily 6 group A member 1 isoform 2
NM_033334.4 NP_201591.2 nuclear receptor subfamily 6 group A member 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NR6A1 蛋白结构

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (59 - 127)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (282 - 455)

  • 0
  • 100
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  • 400
  • 480 a.a.
蛋白主名 其他名称

nuclear receptor subfamily 6 group A member 1

retinoic acid receptor-related testis-associated receptor

NR6A1 抗体

目录号 产品名 应用 反应物种
HY-P84587 NR6A1 Antibody (YA4284) WB, IHC-P, ICC/IF, FC, ELISA Human

关联疾病

疾病名称 别名
Embryonal Carcinoma

Embryonal Neoplasm

Embryonal Cancer

Primary Extragonadal Embryonal Carcinoma

Embryo Neoplasm

Carcinoma Embryonal

Cancer Embryonal

Carcinoma, Embryonal

Extragonadal Embryonal Carcinoma

Cancer, Embryonal
Teratocarcinoma

Mixed Embryonal Carcinoma And Teratoma
Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic
46,Xy Sex Reversal

Swyer Syndrome

Pure Gonadal Dysgenesis 46,Xy

Gonadal Dysgenesis, Xy Female Type

Gonadal Dysgenesis, 46,Xy

46,Xy Cgd

46,Xy Complete Gonadal Dysgenesis

46,Xy Pure Gonadal Dysgenesis

46 Xy Gonadal Dysgenesis

46, Xy Cgd

46, Xy Complete Gonadal Dysgenesis

46, Xy Pure Gonadal Dysgenesis

Xy Pure Gonadal Dysgenesis

Female With 46,Xy Karyotype

Xy Females
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09555 NR6A1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22688 Nr6a1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29202 Nr6a1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus NR6A1 VGNC VGNC:32250
Canis familiaris NR6A1 VGNC VGNC:49931
Macaca mulatta NR6A1 VGNC VGNC:75522
Rattus norvegicus NR6A1 RGD RGD:1564740
Felis catus NR6A1 VGNC VGNC:68558
Mus musculus NR6A1 MGD MGI:1352459
Others NR6A1 NCBI
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